Serena Caminito

TL;DR: Although the data do not exclude that proteolysis of native LC dimers may destabilize their structure and favor fibril formation, the data show that LC deposition largely precedes the proteolytic events documentable in mature AL fibrils.

TL;DR: This paper identified and compared the fragmentation sites of amyloid light chains (LCs) from multiple organs of an AL-55 patient, including kidney and subcutaneous fat, alongside those previously detected in heart of the same patient, were aligned and mapped on the LC's dimeric and fibrillar states.

TL;DR: In this article , the authors exploited LC sequence information from previously published amyloidogenic and control clonal LCs and from a series of 220 patients with multiple myeloma followed at their Institutions to define sequence and spatial features of N-glycosylation, combining bioinformatics, biochemical, proteomics, structural and genetic analyses.

TL;DR: The resulting methodology, termed Single-Molecule Real-Time Sequencing of the M protein (SMaRT M-Seq), identifies the full-length sequence of the variable region of expressed immunoglobulin genes and ranks the obtained sequences based on their relative abundance, thus enabling the identification of thefull-length variable sequence of light and/or heavy chains from a high number of patients analyzed in parallel.

TL;DR: It is reported that an astonishing 57-73% of early deceased short-hair cats kept in three independent shelters suffer from amyloid deposition in the liver, spleen, or kidney and presence of SAA fragments in bile secretions raises the possibility of fecal-oral transmission of the disease.