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Serge Przedborski

Researcher at Columbia University

Publications -  257
Citations -  51906

Serge Przedborski is an academic researcher from Columbia University. The author has contributed to research in topics: Neurodegeneration & MPTP. The author has an hindex of 110, co-authored 249 publications receiving 47514 citations. Previous affiliations of Serge Przedborski include University of South Alabama & Columbia University Medical Center.

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Journal ArticleDOI

Parkinson's disease: Mechanisms and models

William T. Dauer, +1 more
- 11 Sep 2003 - 
TL;DR: PD models based on the manipulation of PD genes should prove valuable in elucidating important aspects of the disease, such as selective vulnerability of substantia nigra dopaminergic neurons to the degenerative process.
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Guidelines for the use and interpretation of assays for monitoring autophagy

Daniel J. Klionsky, +1287 more
- 01 Apr 2012 - 
TL;DR: These guidelines are presented for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
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PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

Cristofol Vives-Bauza, +18 more
- 05 Jan 2010 - 
TL;DR: It is suggested that Parkin, together with PINK1, modulates mitochondrial trafficking, especially to the perinuclear region, a subcellular area associated with autophagy, which may alter mitochondrial turnover which, in turn, may cause the accumulation of defective mitochondria and, ultimately, neurodegeneration in Parkinson's disease.
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Blockade of Microglial Activation Is Neuroprotective in the 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine Mouse Model of Parkinson Disease

Du Chu Wu, +8 more
- 01 Mar 2002 - 
TL;DR: It is shown that minocycline, an approved tetracycline derivative that inhibits microglial activation independently of its antimicrobial properties, mitigates both the demise of nigrostriatal dopaminergic neurons and the formation of nitrotyrosine produced by MPTP.
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Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

Makiko Nagai, +6 more
- 01 May 2007 - 
TL;DR: It is shown that expression of mutated human SOD1 in primary mouse spinal motor neurons does not provoke motor neuron degeneration, and indicates that astrocytes may play a role in the specific degeneration of spinal motor neuron neurons in ALS.