S
Sergei I. Grivennikov
Researcher at Fox Chase Cancer Center
Publications - 86
Citations - 25766
Sergei I. Grivennikov is an academic researcher from Fox Chase Cancer Center. The author has contributed to research in topics: Cancer & Inflammation. The author has an hindex of 44, co-authored 72 publications receiving 21178 citations. Previous affiliations of Sergei I. Grivennikov include Cedars-Sinai Medical Center & Engelhardt Institute of Molecular Biology.
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Journal ArticleDOI
Immunity, Inflammation, and Cancer
TL;DR: The principal mechanisms that govern the effects of inflammation and immunity on tumor development are outlined and attractive new targets for cancer therapy and prevention are discussed.
Journal ArticleDOI
IL-6 and Stat3 Are Required for Survival of Intestinal Epithelial Cells and Development of Colitis-Associated Cancer
Sergei I. Grivennikov,Eliad Karin,Janoš Terzić,Janoš Terzić,Daniel Mucida,Guann-Yi Yu,Sivakumar Vallabhapurapu,Jürgen Scheller,Stefan Rose-John,Hilde Cheroutre,Lars Eckmann,Michael Karin +11 more
TL;DR: It is demonstrated that IL-6 is a critical tumor promoter during early CAC tumorigenesis and the NF-kappaB-IL-6-Stat3 cascade is an important regulator of the proliferation and survival of tumor-initiating IECs.
Journal ArticleDOI
Inflammation and Colon Cancer
TL;DR: The role of distinct immune cells, cytokines, and other immune mediators in virtually all steps of colon tumorigenesis, including initiation, promotion, progression, and metastasis, are elucidated.
Journal ArticleDOI
Inflammation and Cancer: Triggers, Mechanisms, and Consequences.
TL;DR: How tumor-promoting inflammation closely resembles inflammatory processes typically found during development, immunity, maintenance of tissue homeostasis, or tissue repair is discussed and the distinctions between tissue-protective and pro-tumorigenic inflammation are illuminated.
Journal ArticleDOI
Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth.
Sergei I. Grivennikov,Kepeng Wang,Daniel Mucida,C. Andrew Stewart,Bernd Schnabl,Dominik Jauch,Koji Taniguchi,Guann-Yi Yu,Christoph H. Österreicher,Kenneth E. Hung,Christian Datz,Ying Feng,Eric R. Fearon,Mohamed Oukka,Lino Tessarollo,Vincenzo Coppola,Felix Yarovinsky,Hilde Cheroutre,Lars Eckmann,Giorgio Trinchieri,Michael Karin +20 more
TL;DR: It is proposed that barrier deterioration induced by colorectal-cancer-initiating genetic lesions results in adenoma invasion by microbial products that trigger tumour-elicited inflammation, which in turn drives tumour growth.