Author
Sergei V. Dzyadevych
Other affiliations: National Academy of Sciences of Ukraine, Claude Bernard University Lyon 1, Institute of Molecular Biology and Genetics of NASU ...read more
Bio: Sergei V. Dzyadevych is an academic researcher from Taras Shevchenko National University of Kyiv. The author has contributed to research in topics: Biosensor & Glucose oxidase. The author has an hindex of 29, co-authored 105 publications receiving 2710 citations. Previous affiliations of Sergei V. Dzyadevych include National Academy of Sciences of Ukraine & Claude Bernard University Lyon 1.
Papers published on a yearly basis
Papers
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TL;DR: It has finally appeared that these biosensors are quite sensitive to Cd2+ and Zn2+ (limits of detection (LOD) = 10 ppb for a 30 min long exposure) while Pb2+ gives no significant inhibition as this ion seems to adsorb on albumin preferably.
196 citations
TL;DR: The specifications obtained for the detection of different pesticides, herbicides and heavy metal ions, based on enzyme inhibition, are presented as well as those obtained forthe detection of formaldehyde, 4- chlorophenol, nitrate and proteins as markers of dissolved organic carbon based on enzymatic microbiosensors.
Abstract: This review presents the principles of conductometric measurements in ionic media and the equivalent electrical circuits of different designs for conductometric measurements. These types of measurements were first applied for monitoring biocatalytic reactions. The use of conductometric microtransducers is then presented and detailed in the case of pollutant detection for environmental monitoring. Conductometric biosensors have advantages over other types of transducers: they can be produced through inexpensive thinfilm standard technology, no reference electrode is needed and differential mode measurements allow cancellation of a lot of interferences. The specifications obtained for the detection of different pesticides, herbicides and heavy metal ions, based on enzyme inhibition, are presented as well as those obtained for the detection of formaldehyde, 4- chlorophenol, nitrate and proteins as markers of dissolved organic carbon based on enzymatic microbiosensors.
191 citations
TL;DR: In this article, three groups of the amperomettic biosensors such as unmediated, mediated and based on direct transfer of electrons have been thoroughly described, and their advantages and disadvantages were shown.
Abstract: Three groups of the amperomettic biosensors such as unmediated, mediated and based on direct transfer of electrons have been thoroughly described, and their advantages and disadvantages were shown. The amperometric biosensors are mostly utilized in commercial devices since they are studied to a greater extent and have some advantages. The modem commercial systems based on amperometric biosensors and its applications have been presented. The major field of employing biosensors is medical diagnostics where numerous commercial devices are currently functioning.
147 citations
TL;DR: It finally appeared that conductometric biosensors using algae seemed more sensitive than bioassays to detect low levels of cadmium ions (the detection limit for the first experiments was 1 ppb of Cd2+).
127 citations
TL;DR: The key theoretical principles of the work on ion-selective field-effect transistor connected with their application in bioanalytical practice, some specifics of modern microtechnologies for their creation, and measurement schemes with set-ups are discussed.
117 citations
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TL;DR: In this article, the most common traditional traditional techniques, such as cyclic voltammetry, chronoamperometry, chronopotentiometry, impedance spectroscopy, and various field-effect transistor based methods are presented along with selected promising novel approaches, including nanowire or magnetic nanoparticle-based biosensing.
Abstract: Quantification of biological or biochemical processes are of utmost importance for medical, biological and biotechnological applications. However, converting the biological information to an easily processed electronic signal is challenging due to the complexity of connecting an electronic device directly to a biological environment. Electrochemical biosensors provide an attractive means to analyze the content of a biological sample due to the direct conversion of a biological event to an electronic signal. Over the past decades several sensing concepts and related devices have been developed. In this review, the most common traditional techniques, such as cyclic voltammetry, chronoamperometry, chronopotentiometry, impedance spectroscopy, and various field-effect transistor based methods are presented along with selected promising novel approaches, such as nanowire or magnetic nanoparticle-based biosensing. Additional measurement techniques, which have been shown useful in combination with electrochemical detection, are also summarized, such as the electrochemical versions of surface plasmon resonance, optical waveguide lightmode spectroscopy, ellipsometry, quartz crystal microbalance, and scanning probe microscopy. The signal transduction and the general performance of electrochemical sensors are often determined by the surface architectures that connect the sensing element to the biological sample at the nanometer scale. The most common surface modification techniques, the various electrochemical transduction mechanisms, and the choice of the recognition receptor molecules all influence the ultimate sensitivity of the sensor. New nanotechnology-based approaches, such as the use of engineered ion-channels in lipid bilayers, the encapsulation of enzymes into vesicles, polymersomes, or polyelectrolyte capsules provide additional possibilities for signal amplification. In particular, this review highlights the importance of the precise control over the delicate interplay between surface nano-architectures, surface functionalization and the chosen sensor transducer principle, as well as the usefulness of complementary characterization tools to interpret and to optimize the sensor response.
1,550 citations
TL;DR: Although there remain many unanswered questions, particularly regarding the mechanisms by which electrical conduction through CPs affects cells, there is already compelling evidence to demonstrate the significant impact that CPs are starting to make in the biomedical field.
1,429 citations
TL;DR: The description and discussion of the major applications of hybrid inorganic-organic (or biologic) materials are the major topic of this critical review.
Abstract: Today cross-cutting approaches, where molecular engineering and clever processing are synergistically coupled, allow the chemist to tailor complex hybrid systems of various shapes with perfect mastery at different size scales, composition, functionality, and morphology. Hybrid materials with organic–inorganic or bio–inorganic character represent not only a new field of basic research but also, via their remarkable new properties and multifunctional nature, hybrids offer prospects for many new applications in extremely diverse fields. The description and discussion of the major applications of hybrid inorganic–organic (or biologic) materials are the major topic of this critical review. Indeed, today the very large set of accessible hybrid materials span a wide spectrum of properties which yield the emergence of innovative industrial applications in various domains such as optics, micro-electronics, transportation, health, energy, housing, and the environment among others (526 references).
1,159 citations
TL;DR: The choice of the immobilization method is shown to represent an important parameter that affects biosensor performances, mainly in terms of sensitivity, selectivity and stability, by influencing enzyme orientation, loading, mobility, stability, structure and biological activity.
886 citations
TL;DR: The aim of this review is to describe the chemical characteristics of compounds present in honey, their stability when heated or stored for long periods of time and the parameters of identity and quality.
810 citations