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Sergii Dudkin

Bio: Sergii Dudkin is an academic researcher from University of Rostock. The author has contributed to research in topics: Indole test & Reactivity (chemistry). The author has an hindex of 10, co-authored 22 publications receiving 190 citations.

Papers
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Journal ArticleDOI
TL;DR: In this article, the starting materials were prepared by the reaction of 4-hydroxycoumarin with trifluoroacetic anhydride and methyl 2-chloro-2-oxoacetate in the presence of trimethylsilylchloride.

38 citations

Journal ArticleDOI
TL;DR: The first synthesis of 3-methoxalylchromone was described, where the reaction of the latter with electron-rich aminoheterocycles afforded a set of heteroannelated pyridines bearing a CO(2)Me substituent located at the α-position of the pyridine core.
Abstract: The first synthesis of 3-methoxalylchromone was described. The reaction of the latter with electron-rich aminoheterocycles afforded a set of heteroannelated pyridines bearing a CO2Me substituent located at the α-position of the pyridine core.

34 citations

Journal ArticleDOI
TL;DR: The reaction of 4-chloro-3-( trifluoroacetyl)coumarin with commercially available anilines is a two-step method, which affords a set of 7-(trifluoromethyl)-6 H -chromeno[4,3- b ]quinolin-6-ones in good to excellent yields.

30 citations

Journal ArticleDOI
TL;DR: In this paper, the reaction of electron-rich aminoheterocycles with 1,3-CCC -dielectrophiles, such as 3-formylchromones,acylpyruvates, and chalcone, provided diversely fused pyridines.
Abstract: The reaction of electron-rich aminoheterocycles with 1,3-CCC -dielectrophiles, such as 3-formylchromones,acylpyruvates, and chalcone, provided diversely fused pyridines.Starting from 5-amino-1-(2,3- O-isopropylidene-β- D-ribofuranosyl)-1 H-pyrazole,nucleosides containing a pyrazolo[3,4- B]pyridinefragment were obtained, which can be considered as adenosine deaminase(ADA) inhibitors.

19 citations

Journal ArticleDOI
TL;DR: A facile synthetic approach for the synthesis of 1,8-naphthyridine-4(1H)-one derivatives via a catalyst free and Pd-supported tandem amination sequence is developed and described.
Abstract: A facile synthetic approach for the synthesis of 1,8-naphthyridine-4(1H)-one derivatives via a catalyst free and Pd-supported tandem amination sequence is developed and described In a case of aliphatic amines reaction proceeds in a catalyst free mode, however anilines demand Pd-supported reaction conditions

15 citations


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Patent
11 Jul 2013
TL;DR: In this article, the present invention provides thienopyridine compounds, compositions thereof, and methods of using the same, as well as methods of obtaining the same from the same.
Abstract: The present invention provides thienopyridine compounds, compositions thereof, and methods of using the same.

92 citations

Journal ArticleDOI
TL;DR: Chalcones belong to the flavonoid family and constitute one of the major classes of naturally occurring oxygen heterocyclic compounds, leading to the synthesis of promising bioactive compounds as mentioned in this paper.
Abstract: Chalcones belong to the flavonoid family which constitutes one of the major classes of naturally occurring oxygen heterocyclic compounds. The , -unsaturated carbonyl system of chalcones possesses two electrophilic reactive centers allowing them to participate in addition reactions via attack to the carbonyl group (1,2-addition) or involving the -carbon (1,4-conjugate addition), leading to the synthesis of promising bioactive heterocyclic compounds. The purpose of this review is to present a systematic survey of the most recent literature that uses chalcones in the synthesis of biologically active 5and 6-membered nitrogen heterocycles such as pyrroles, indoles, isoxazoles, imidazoles, pyrazoles, indazoles, triazoles, tetrazoles, pyridines and pyrimidines. Efficiency, easy-to-handle and cheap reagents, alternative heating conditions and greener protocols will be highlighted. In this review we will cover the literature since the beginning of the 21 century in more than 400 publications.

77 citations

Journal ArticleDOI
TL;DR: Barbituric acid has been utilized in the design and synthesis of diverse types of heterocyclic and carbcycle-clic compounds and considered as an important building block in organic synthesis as mentioned in this paper.
Abstract: Barbituric acid has been utilized in the design and synthesis of diverse types of heterocyclic and carbocyclic compounds and considered as an important building block in organic synthesis. There is a wide range of multicomponent reactions that include barbituric acid as starting material. This article aims to review the chemistry of barbituric acids employed in the design and synthesis of different types of compounds during the period from 2011 to 2015.

72 citations