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Sergio A. Jimenez

Researcher at Thomas Jefferson University

Publications -  422
Citations -  31036

Sergio A. Jimenez is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Gene expression & Procollagen peptidase. The author has an hindex of 84, co-authored 416 publications receiving 28486 citations. Previous affiliations of Sergio A. Jimenez include Franklin Institute & Hospital of the University of Pennsylvania.

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2013 classification criteria for systemic sclerosis: An american college of rheumatology/European league against rheumatism collaborative initiative

Frank H J van den Hoogen, +46 more
TL;DR: The ACR/EULAR classification criteria for SSc performed better than the 1980 ACR criteria and should allow for more patients to be classified correctly as having the disease.
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2013 classification criteria for systemic sclerosis: an American college of rheumatology/European league against rheumatism collaborative initiative

Frank H J van den Hoogen, +46 more
TL;DR: The ACR/EULAR classification criteria for SSc performed better than the 1980 ACR criteria and should allow for more patients to be classified correctly as having the disease.
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Osteoarthritis cartilage histopathology: grading and staging

TL;DR: The OARSI cartilage OA histopathology grading system appears consistent and simple to apply as discussed by the authors, however, further studies are required to confirm the system's utility, as well as their reproducibility and validity.
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NF-κB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis

TL;DR: Promising strategies such as improved antisense DNA therapy and RNA interference have been examined with encouraging results, but further research will be needed before NF-κB-aimed strategies become an effective therapy for joint diseases, such as OA and RA.
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Transforming growth factor beta (TGF beta) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts.

TL;DR: The results indicate that TGF beta causes a marked enhancement of the production of types I and III collagens and fibronectin by cultured normal human dermal fibroblasts and may contribute to the development of pathological states of fibrosis.