S
Sergio I. Valdés-Ferrer
Researcher at The Feinstein Institute for Medical Research
Publications - 74
Citations - 3886
Sergio I. Valdés-Ferrer is an academic researcher from The Feinstein Institute for Medical Research. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 18, co-authored 50 publications receiving 2984 citations. Previous affiliations of Sergio I. Valdés-Ferrer include National Autonomous University of Mexico & North Shore-LIJ Health System.
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Journal ArticleDOI
Acetylcholine-synthesizing T cells relay neural signals in a vagus nerve circuit.
Mauricio Rosas-Ballina,Peder S. Olofsson,Mahendar Ochani,Sergio I. Valdés-Ferrer,Yaakov A. Levine,Colin Reardon,Michael W. Tusche,Valentin A. Pavlov,Ulf Andersson,Sangeeta S. Chavan,Tak W. Mak,Kevin J. Tracey +11 more
TL;DR: This work has identified an acetylcholine-producing, memory phenotype T cell population in mice that is integral to the inflammatory reflex, and action potentials originating in the vagus nerve regulate T cells, which in turn produce the neurotransmitters required to control innate immune responses.
Journal ArticleDOI
Novel role of PKR in inflammasome activation and HMGB1 release
Ben Lu,Takahisa Nakamura,Karen Inouye,Jianhua Li,Yiting Tang,Peter Lundbäck,Sergio I. Valdés-Ferrer,Peder S. Olofsson,Thomas Kalb,Jesse Roth,Yongrui Zou,Helena Erlandsson-Harris,Huan Yang,Jenny P.-Y. Ting,Haichao Wang,Ulf Andersson,Daniel J. Antoine,Sangeeta S. Chavan,Gökhan S. Hotamisligil,Kevin J. Tracey +19 more
TL;DR: Results show a crucial role for PKR in inflammasome activation, and indicate that it should be possible to pharmacologically target this molecule to treat inflammation.
Journal ArticleDOI
MD-2 is required for disulfide HMGB1-dependent TLR4 signaling
Huan Yang,Haichao Wang,Zhongliang Ju,Ahmed A. Ragab,Peter Lundbäck,Wei Long,Sergio I. Valdés-Ferrer,Mingzhu He,John P. Pribis,Jianhua Li,Ben Lu,Domokos Gero,Csaba Szabó,Daniel J. Antoine,Helena Erlandsson Harris,Doug T. Golenbock,Jianmin Meng,Jesse Roth,Sangeeta S. Chavan,Ulf Andersson,Timothy R. Billiar,Kevin J. Tracey,Yousef Al-Abed +22 more
TL;DR: An HGMB1 peptide inhibitor, P5779, which when administered in vivo can protect mice from acetaminophen-induced hepatoxicity, ischemia/reperfusion injury, and sepsis, is identified.
Journal ArticleDOI
Systemic inflammation and the brain: novel roles of genetic, molecular, and environmental cues as drivers of neurodegeneration.
TL;DR: Recent genetic evidence suggesting an association between neurodegenerative disorders and persistent immune activation; clinical and experimental evidence indicating previously unidentified immune-mediated pathways of neurodegenersation; and novel immunomodulatory targets and their potential relevance for neurodegnerative disorders are reviewed.
Journal ArticleDOI
HMGB1 mediates cognitive impairment in sepsis survivors.
Sangeeta S. Chavan,Patricio T. Huerta,Sergio Robbiati,Sergio I. Valdés-Ferrer,Mahendar Ochani,Meghan Dancho,Maya Frankfurt,Bruce T. Volpe,Kevin J. Tracey,Betty Diamond +9 more
TL;DR: It is observed that serum levels of high mobility group box 1 (HMGB1), a critical mediator of acute sepsis pathophysiology, are increased and this indicates that elevated HMGB1 levels mediate cognitive decline in sepsi survivors, and it is suggested that it may be possible to prevent or reverse cognitive impairments in Sepsis survivors by administration of anti-HMGB 1 antibodies.