Seung-Hee Lee

TL;DR: Current understanding of the key neural circuits involved in regulating brain states, with a particular emphasis on the subcortical neuromodulatory systems are summarized.

TL;DR: In this article, an optogenetic activation of parvalbumin-positive (PV+) interneurons in the mouse primary visual cortex (V1) sharpens neuronal feature selectivity and improves perceptual discrimination.

TL;DR: It is shown that basal forebrain cholinergic neurons rapidly regulate cortical activity and visual perception in awake, behaving mice, and optogenetic activation of the cholinergy neurons or their V1 axon terminals improved performance of a visual discrimination task on a trial-by-trial basis.

TL;DR: It is shown that optogenetic activation of parvalbumin-positive (PV+) interneurons in the mouse primary visual cortex (V1) sharpens neuronal feature selectivity and improves perceptual discrimination, the first demonstration that visual coding and perception can be improved by increased spiking of a specific subtype of cortical inhibitory interneuron.

TL;DR: A new tool for intracellular delivery of target proteins, named ‘exosomes for protein loading via optically reversible protein–protein interactions’ (EXPLORs), which is able to successfully load cargo proteins into newly generated exosomes using optogenetic control of protein-protein interactions between the cargo and an exosome-localized partner.