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Seung Wook Oh
Researcher at Allen Institute for Brain Science
Publications - 20
Citations - 10906
Seung Wook Oh is an academic researcher from Allen Institute for Brain Science. The author has contributed to research in topics: Daf-16 & Caenorhabditis elegans. The author has an hindex of 17, co-authored 19 publications receiving 8494 citations. Previous affiliations of Seung Wook Oh include University of Massachusetts Medical School.
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Journal ArticleDOI
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Linda Madisen,Theresa A. Zwingman,Susan M. Sunkin,Seung Wook Oh,Hatim A. Zariwala,Hong Gu,Lydia Ng,Richard D. Palmiter,Michael Hawrylycz,Allan R. Jones,Ed S. Lein,Hongkui Zeng +11 more
TL;DR: A set of Cre reporter mice with strong, ubiquitous expression of fluorescent proteins of different spectra is generated and enables direct visualization of fine dendritic structures and axonal projections of the labeled neurons, which is useful in mapping neuronal circuitry, imaging and tracking specific cell populations in vivo.
Journal ArticleDOI
A mesoscale connectome of the mouse brain
Seung Wook Oh,Julie A. Harris,Lydia Ng,Brent Winslow,Nicholas Cain,Stefan Mihalas,Quanxin Wang,Chris Lau,Leonard Kuan,Alex M. Henry,Marty Mortrud,Benjamin Ouellette,Thuc Nghi Nguyen,Staci A. Sorensen,Clifford R. Slaughterbeck,Wayne Wakeman,Yang Li,David Feng,Anh Ho,Eric Nicholas,Karla E. Hirokawa,Phillip Bohn,Kevin M. Joines,Hanchuan Peng,Michael Hawrylycz,John W. Phillips,John G. Hohmann,Paul Wohnoutka,Charles R. Gerfen,Christof Koch,Amy Bernard,Chinh Dang,Allan R. Jones,Hongkui Zeng +33 more
TL;DR: A brain-wide, cellular-level, mesoscale connectome for the mouse, using enhanced green fluorescent protein-expressing adeno-associated viral vectors to trace axonal projections from defined regions and cell types, and high-throughput serial two-photon tomography to image the EGFP-labelled axons throughout the brain.
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The Allen Mouse Brain Common Coordinate Framework: A 3D Reference Atlas.
Quanxin Wang,Songlin Ding,Yang Li,Josh Royall,David Feng,Phil Lesnar,Nile Graddis,Maitham Naeemi,Benjamin A.C. Facer,Anh Ho,Tim A. Dolbeare,Brandon Blanchard,Nick Dee,Wayne Wakeman,Karla E. Hirokawa,Aaron Szafer,Susan M. Sunkin,Seung Wook Oh,Amy Bernard,John W. Phillips,Michael Hawrylycz,Christof Koch,Hongkui Zeng,Julie A. Harris,Lydia Ng +24 more
TL;DR: This work constructed an average template brain at 10 μm voxel resolution by interpolating high resolution in-plane serial two-photon tomography images with 100 μm z-sampling from 1,675 young adult C57BL/6J mice and parcellated the entire brain directly in 3D.
Journal ArticleDOI
JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16
Seung Wook Oh,Arnab Mukhopadhyay,Nenad Svrzikapa,Feng Jiang,Roger J. Davis,Heidi A. Tissenbaum +5 more
TL;DR: This work demonstrates that c-Jun N-terminal kinase (JNK) is a positive regulator of DAF-16 in both lifespan regulation and stress resistance and defines an interaction between two well conserved proteins, JNK-1 and D AF-16, and provides a mechanism by which JNK regulates longevity and stress Resistance.
Journal ArticleDOI
Identification of direct DAF-16 targets controlling longevity, metabolism and diapause by chromatin immunoprecipitation.
Seung Wook Oh,Arnab Mukhopadhyay,Bharat L. Dixit,Tamal Raha,Michael R. Green,Heidi A. Tissenbaum +5 more
TL;DR: The results show that the ChIP-based cloning strategy leads to greater enrichment for DAF-16 target genes than previous screening strategies, and it is demonstrated that Daf-16 is recruited to multiple promoters to coordinate regulation of its downstream targets.