S
Seyedeh M. Zekavat
Researcher at Yale University
Publications - 88
Citations - 4352
Seyedeh M. Zekavat is an academic researcher from Yale University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 24, co-authored 65 publications receiving 2337 citations. Previous affiliations of Seyedeh M. Zekavat include Harvard University & Broad Institute.
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Journal ArticleDOI
A Genetic Variant Associated with Five Vascular Diseases Is a Distal Regulator of Endothelin-1 Gene Expression
Rajat M. Gupta,Joseph E. Hadaya,Aditi Trehan,Seyedeh M. Zekavat,Carolina Roselli,Derek Klarin,Connor A. Emdin,Catharina R.E. Hilvering,Valerio Bianchi,Christian Mueller,Amit Khera,Russell J.H. Ryan,Jesse M. Engreitz,Robbyn Issner,Noam Shoresh,Charles B. Epstein,Wouter de Laat,Jonathan D. Brown,Renate B. Schnabel,Bradley E. Bernstein,Sekar Kathiresan +20 more
TL;DR: CRISPR-edited stem cell-derived endothelial cells demonstrate rs9349379 regulates expression of endothelin 1 (EDN1), a gene located 600 kb upstream of PHACTR1, which may explain the pattern of risk for the five associated diseases.
Journal ArticleDOI
Inherited causes of clonal haematopoiesis in 97,691 whole genomes.
Alexander G. Bick,Joshua S. Weinstock,Satish K. Nandakumar,Satish K. Nandakumar,Charles P. Fulco,Charles P. Fulco,Erik L. Bao,Erik L. Bao,Seyedeh M. Zekavat,Seyedeh M. Zekavat,Mindy D. Szeto,Xiaotian Liao,Xiaotian Liao,Matthew Leventhal,Joseph Nasser,Kyle Chang,Cecelia A. Laurie,Bala Bharathi Burugula,Christopher J. Gibson,Amy E. Lin,Margaret A. Taub,François Aguet,Kristin G. Ardlie,Braxton D. Mitchell,Braxton D. Mitchell,Kathleen C. Barnes,Kathleen C. Barnes,Arden Moscati,Myriam Fornage,Susan Redline,Susan Redline,Susan Redline,Bruce M. Psaty,Edwin K. Silverman,Edwin K. Silverman,Scott T. Weiss,Scott T. Weiss,Nicholette D. Palmer,Ramachandran S. Vasan,Esteban G. Burchard,Sharon L.R. Kardia,Jiang He,Robert C. Kaplan,Robert C. Kaplan,Nicholas L. Smith,Nicholas L. Smith,Nicholas L. Smith,Donna K. Arnett,David A. Schwartz,Adolfo Correa,Mariza de Andrade,Xiuqing Guo,Barbara A. Konkle,Brian Custer,Juan M. Peralta,Hongsheng Gui,Deborah A. Meyers,Stephen T. McGarvey,Ida Yii-Der Chen,M. Benjamin Shoemaker,Patricia A. Peyser,Jai G. Broome,Stephanie M. Gogarten,Fei Fei Wang,Quenna Wong,May E. Montasser,Michelle Daya,Eimear E. Kenny,Kari E. North,Lenore J. Launer,Brian E. Cade,Brian E. Cade,Joshua C. Bis,Michael H. Cho,Michael H. Cho,Jessica Lasky-Su,Jessica Lasky-Su,Donald W. Bowden,L. Adrienne Cupples,Angel C.Y. Mak,Lewis C. Becker,Jennifer A. Smith,Tanika N. Kelly,Stella Aslibekyan,Susan R. Heckbert,Susan R. Heckbert,Hemant K. Tiwari,Ivana V. Yang,John A. Heit,Steven A. Lubitz,Steven A. Lubitz,Jill M. Johnsen,Joanne E. Curran,Sally E. Wenzel,Daniel E. Weeks,Dabeeru C. Rao,Dawood Darbar,Jee-Young Moon,Russell P. Tracy,Erin J Buth,Nicholas Rafaels,Ruth J. F. Loos,Peter Durda,Yongmei Liu,Lifang Hou,Jiwon Lee,Priyadarshini Kachroo,Priyadarshini Kachroo,Barry I. Freedman,Daniel Levy,Lawrence F. Bielak,James E. Hixson,James S. Floyd,Eric A. Whitsel,Patrick T. Ellinor,Patrick T. Ellinor,Marguerite R. Irvin,Tasha E. Fingerlin,Laura M. Raffield,Sebastian M. Armasu,Marsha M. Wheeler,Ester Cerdeira Sabino,John Blangero,L. Keoki Williams,Bruce D. Levy,Bruce D. Levy,Wayne Huey-Herng Sheu,Dan M. Roden,Eric Boerwinkle,Eric Boerwinkle,JoAnn E. Manson,JoAnn E. Manson,Rasika A. Mathias,Pinkal Desai,Kent D. Taylor,Andrew D. Johnson,Paul L. Auer,Charles Kooperberg,Cathy C. Laurie,Thomas W. Blackwell,Albert V. Smith,Hongyu Zhao,Ethan M. Lange,Leslie A. Lange,Stephen S. Rich,Jerome I. Rotter,James G. Wilson,James G. Wilson,Paul Scheet,Jacob O. Kitzman,Eric S. Lander,Eric S. Lander,Eric S. Lander,Jesse M. Engreitz,Jesse M. Engreitz,Benjamin L. Ebert,Alexander P. Reiner,Alexander P. Reiner,Siddhartha Jaiswal,Gonçalo R. Abecasis,Gonçalo R. Abecasis,Vijay G. Sankaran,Vijay G. Sankaran,Sekar Kathiresan,Pradeep Natarajan,Pradeep Natarajan +165 more
TL;DR: Analysis of high-coverage whole-genome sequences from 97,691 participants of diverse ancestries in the National Heart, Lung, and Blood Institute Trans-omics for Precision Medicine programme enables simultaneous identification of germline and somatic mutations that predispose individuals to clonal expansion of haematopoietic stem cells.
Journal ArticleDOI
ANGPTL3 Deficiency and Protection Against Coronary Artery Disease
Nathan O. Stitziel,Amit Khera,Xiao Wang,Andrew J. Bierhals,A. Christina Vourakis,Alexandra E Sperry,Pradeep Natarajan,Derek Klarin,Connor A. Emdin,Seyedeh M. Zekavat,Akihiro Nomura,Jeanette Erdmann,Heribert Schunkert,Nilesh J. Samani,William E. Kraus,Svati H. Shah,Bing Yu,Eric Boerwinkle,Daniel J. Rader,Namrata Gupta,Philippe M. Frossard,Asif Rasheed,John Danesh,Eric S. Lander,Stacey Gabriel,Danish Saleheen,Kiran Musunuru,Sekar Kathiresan,Promis +28 more
TL;DR: ANGPTL3 deficiency is associated with protection from CAD, and individuals in the lowest tertile of circulating ANGPTL 3 concentrations, compared with the highest, had reduced odds of MI.
Journal ArticleDOI
Genetic Association of Waist-to-Hip Ratio With Cardiometabolic Traits, Type 2 Diabetes, and Coronary Heart Disease.
Connor A. Emdin,Amit Khera,Pradeep Natarajan,Derek Klarin,Seyedeh M. Zekavat,Allan J. Hsiao,Sekar Kathiresan +6 more
TL;DR: Analysis of summary-level genome-wide association study results and individual-level UK Biobank data demonstrated that a 1-SD increase in WHR adjusted for BMI mediated by the polygenic risk score was associated with increased risk of type 2 diabetes and coronary heart disease.
Journal ArticleDOI
Association of Premature Natural and Surgical Menopause With Incident Cardiovascular Disease
Michael C. Honigberg,Seyedeh M. Zekavat,Seyedeh M. Zekavat,Seyedeh M. Zekavat,Krishna G. Aragam,Phoebe Finneran,Derek Klarin,Derek Klarin,Deepak L. Bhatt,James L. Januzzi,Nandita S. Scott,Pradeep Natarajan +11 more
TL;DR: Natural and surgical premature menopause (before age 40 years) were associated with a small but statistically significant increased risk for a composite of cardiovascular diseases among postmenopausal women.