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Seyedmohammad Hossaini

Bio: Seyedmohammad Hossaini is an academic researcher from Islamic Azad University. The author has contributed to research in topics: Crocin & Rotenone. The author has an hindex of 1, co-authored 1 publications receiving 1 citations.
Topics: Crocin, Rotenone, Kidney, Toxicity

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TL;DR: The crocin has protective influence on histopathological changes in rat kidney following rotenone administration, which was observed in the form of vacuole degeneration, hyperemia and influx of inflammatory cells.
Abstract: Background: Rotenone is one of the most widely used pesticides in agriculture and may affect public health through the food chain. A possible mechanism of rotenone toxicity is oxidative stress. This study, the supportive effect of crocin (a substance derived from saffron) as an antioxidant on the renal toxicity of rotenone in an experimental animal model was investigated. Methods: First, male rats were divided into 4 groups (6 in each group) and received saline, crocin, rotenone and rotenone-crocin combination intraperitoneally for 10 days, respectively. Blood and kidney tissue samples were then isolated and biochemical factors including creatinine, nitrogen blood urea (BUN), sodium, potassium, Malondialdehyde and catalase were measured. The kidneys were examined histopathologically with a light microscope. Results: The results showed that rotenone caused damage to kidney tissue, which was observed in the form of vacuole degeneration, hyperemia and influx of inflammatory cells. Crocin has also been shown to reduce the severity of rotenone-induced kidney damage. Also results showed that biochemical changes were not statistically significant between the groups. Conclusions: The crocin has protective influence on histopathological changes in rat᾽s kidney following rotenone administration.

1 citations


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TL;DR: It seems the beneficial effect of crocin was modulating with stimulatory insulin secretion and ameliorative insulin resistance effects causing a protective effect on the disease and its kidney complications.
Abstract: In order to evaluate the alleviative effect of crocin on diabetes mellitus and its kidney complications, the serum levels of glucose, insulin, urea, creatinine and β2M were examined in healthy and streptozotocin-induced diabetic rats after crocin administration. Materials & Methods: In this study 45 rats were divided into 9 groups (5 each) of healthy control, diabetic control, diabetic treatment with crocin (two dose of 10 and 40 mg/kg) and diabetic positive treatment (with insulin 5 mg/kg) in a period of 20 days. Results: The results indicated that the serum levels β2M, urea and creatinine significantly increased in diabetic rats. However, in groups receiving crocin with the dose of 10 and 40 mg/kg the serum levels of β2M were significantly lower than the control diabetic rats showing beneficial effect of crocin preventing diabetic nephropathy. Although the serum levels of urea and creatinine decreased in crocin receiving groups but they did not reach to a significant level. Conclusion: Finally, crocin decreased the serum levels of β2M, glucose, urea and creatinine in diabetes mellitus causing a protective effect on the disease and its kidney complications. It seems the beneficial effect of crocin was modulating with stimulatory insulin secretion and ameliorative insulin resistance effects

5 citations