S
Seyhan Yazar
Researcher at Garvan Institute of Medical Research
Publications - 115
Citations - 3974
Seyhan Yazar is an academic researcher from Garvan Institute of Medical Research. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 28, co-authored 97 publications receiving 2458 citations. Previous affiliations of Seyhan Yazar include University of Edinburgh & Medical Research Council.
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Journal ArticleDOI
Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression
Urmo Võsa,Annique Claringbould,Annique Claringbould,Harm-Jan Westra,Marc Jan Bonder,Patrick Deelen,Biao Zeng,Holger Kirsten,Ashis Saha,Roman Kreuzhuber,Roman Kreuzhuber,Roman Kreuzhuber,Seyhan Yazar,Harm Brugge,Roy Oelen,Dylan H. de Vries,Monique G. P. van der Wijst,Silva Kasela,Natalia Pervjakova,Isabel Alves,Marie-Julie Favé,Mawusse Agbessi,Mark W. Christiansen,Rick Jansen,Ilkka Seppälä,Lin Tong,Alexander Teumer,Katharina Schramm,Gibran Hemani,Joost Verlouw,Hanieh Yaghootkar,Hanieh Yaghootkar,Hanieh Yaghootkar,Reyhan Sönmez Flitman,Reyhan Sönmez Flitman,Andrew A. Brown,Andrew A. Brown,Viktorija Kukushkina,Anette Kalnapenkis,Sina Rüeger,Eleonora Porcu,Jaanika Kronberg,Johannes Kettunen,Bernett Lee,Futao Zhang,Ting Qi,Jose Alquicira Hernandez,Wibowo Arindrarto,Frank Beutner,Peter A C 't Hoen,Joyce B. J. van Meurs,Jenny van Dongen,Maarten van Iterson,Morris A. Swertz,Julia Dmitrieva,Mahmoud Elansary,Benjamin P. Fairfax,Michel Georges,Bastiaan T. Heijmans,Alex W. Hewitt,Mika Kähönen,Yungil Kim,Yungil Kim,Julian C. Knight,Peter Kovacs,Knut Krohn,Shuang Li,Markus Loeffler,Urko M. Marigorta,Urko M. Marigorta,Hailang Mei,Yukihide Momozawa,Martina Müller-Nurasyid,Matthias Nauck,Michel G. Nivard,Brenda W.J.H. Penninx,Jonathan K. Pritchard,Olli T. Raitakari,Olli T. Raitakari,Olaf Rötzschke,Eline Slagboom,Coen D.A. Stehouwer,Michael Stumvoll,Patrick F. Sullivan,Joachim Thiery,Anke Tönjes,Jan H. Veldink,Uwe Völker,Robert Warmerdam,Cisca Wijmenga,Morris Swertz,Anand Kumar Andiappan,Grant W. Montgomery,Samuli Ripatti,Markus Perola,Zoltán Kutalik,Emmanouil T. Dermitzakis,Emmanouil T. Dermitzakis,Sven Bergmann,Sven Bergmann,Timothy M. Frayling,Holger Prokisch,Habibul Ahsan,Brandon L. Pierce,Terho Lehtimäki,Dorret I. Boomsma,Bruce M. Psaty,Sina A. Gharib,Philip Awadalla,Lili Milani,Willem H. Ouwehand,Willem H. Ouwehand,Willem H. Ouwehand,Kate Downes,Kate Downes,Oliver Stegle,Oliver Stegle,Alexis Battle,Peter M. Visscher,Jian Yang,Jian Yang,Markus Scholz,Joseph E. Powell,Joseph E. Powell,Greg Gibson,Tõnu Esko,Lude Franke +126 more
TL;DR: In this article, the authors performed cis-and trans-expression quantitative trait locus (eQTL) analyses using blood-derived expression from 31,684 individuals through the eQTLGen Consortium.
Journal ArticleDOI
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
Yi Lu,Veronique Vitart,Kathryn P. Burdon,Chiea Chuen Khor,Yelena Bykhovskaya,Alireza Mirshahi,Alex W. Hewitt,Alex W. Hewitt,Demelza Koehn,Pirro G. Hysi,Wishal D. Ramdas,Tanja Zeller,Eranga N. Vithana,Belinda K. Cornes,Wan Ting Tay,E. Shyong Tai,Ching-Yu Cheng,Jianjun Liu,Jianjun Liu,Jia Nee Foo,Seang-Mei Saw,Gudmar Thorleifsson,Kari Stefansson,Kari Stefansson,David P. Dimasi,Richard A. Mills,Jenny Mountain,Wei Ang,René Hoehn,Virginie J. M. Verhoeven,Franz H. Grus,Roger C. W. Wolfs,Raphaële Castagné,Karl J. Lackner,Henriët Springelkamp,Jian Yang,Fridbert Jonasson,Dexter Y L Leung,Li J. Chen,Clement C Y Tham,Igor Rudan,Igor Rudan,Zoran Vatavuk,Caroline Hayward,Jane Gibson,Angela J. Cree,Alex MacLeod,Sarah Ennis,Ozren Polasek,Harry Campbell,James F. Wilson,Ananth C. Viswanathan,Brian W Fleck,Xiaohui Li,David S. Siscovick,Kent D. Taylor,Jerome I. Rotter,Seyhan Yazar,Megan Ulmer,Jun Li,Brian L. Yaspan,Ayse Bilge Ozel,Julia E. Richards,Sayoko E. Moroi,Jonathan L. Haines,Jae H. Kang,Louis R. Pasquale,Louis R. Pasquale,R. Rand Allingham,Allison E. Ashley-Koch,Paul Mitchell,Jie Jin Wang,Alan F. Wright,Craig E. Pennell,Tim D. Spector,Terri L. Young,Terri L. Young,Caroline C W Klaver,Nicholas G. Martin,Grant W. Montgomery,Michael G. Anderson,Tin Aung,Colin E. Willoughby,Janey L. Wiggs,Chi P. Pang,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Andrew J. Lotery,Christopher J Hammond,Cornelia M. van Duijn,Michael A. Hauser,Yaron S. Rabinowitz,Norbert Pfeiffer,David A. Mackey,David A. Mackey,Jamie E Craig,Stuart MacGregor,Tien Yin Wong,Tien Yin Wong +98 more
TL;DR: A meta-analysis on >20,000 individuals in European and Asian populations that identified 16 new loci associated with CCT at genome-wide significance showed that 2 CCT-associated loci conferred relatively large risks for keratoconus in 2 cohorts with 874 cases and 6,085 controls.
Journal ArticleDOI
Environmental effects of ozone depletion, UV radiation and interactions with climate change: UNEP Environmental Effects Assessment Panel, update 2017
Germar Bernhard,Rachel E. Neale,Paul Barnes,Patrick J. Neale,Richard G. Zepp,Stephen R. Wilson,Anthony L. Andrady,Alkiviadis F. Bais,Richard McKenzie,Pieter J. Aucamp,Paul Young,J. B. Liley,Robyn M. Lucas,Seyhan Yazar,Lesley E. Rhodes,Scott N. Byrne,L. M. Hollestein,Catherine M. Olsen,Antony R. Young,Thomas Matthew Robson,Janet F. Bornman,Marcel A. K. Jansen,Sharon A. Robinson,Carlos L. Ballaré,Craig E. Williamson,Kevin C. Rose,Anastazia T. Banaszak,Donat-P. Häder,Samuel Hylander,Sten-Åke Wängberg,Amy T. Austin,W. C Hou,Nigel D. Paul,Sasha Madronich,Barbara Sulzberger,Keith R. Solomon,H. Li,T. Schikowski,Janice Longstreth,Krishna K. Pandey,Anu Heikkilä,C. C. White +41 more
TL;DR: The present 2017 Update Report assesses some of the highlights and new insights about the interactive nature of the direct and indirect effects of UV radiation, atmospheric processes, and climate change.
Journal ArticleDOI
Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma
Pirro G. Hysi,Ching-Yu Cheng,Henriët Springelkamp,Stuart MacGregor,Jessica N. Cooke Bailey,Robert Wojciechowski,Robert Wojciechowski,Veronique Vitart,Abhishek Nag,Alex W. Hewitt,René Höhn,Cristina Venturini,Cristina Venturini,Alireza Mirshahi,Wishal D. Ramdas,Gudmar Thorleifsson,Eranga N. Vithana,Chiea Chuen Khor,Chiea Chuen Khor,Arni B Stefansson,Jiemin Liao,Jonathan L. Haines,Najaf Amin,Ya Xing Wang,Philipp S. Wild,Ayse Bilge Ozel,Jun Li,Brian W Fleck,Tanja Zeller,Sandra E Staffieri,Yik Ying Teo,Gabriel Cuellar-Partida,Xiaoyan Luo,R. Rand Allingham,Julia E. Richards,Andrea Senft,Lennart C. Karssen,Yingfeng Zheng,Céline Bellenguez,Céline Bellenguez,Céline Bellenguez,Liang Xu,Adriana I Iglesias,James F. Wilson,Jae H. Kang,Elisabeth M. van Leeuwen,Vesteinn Jonsson,Unnur Thorsteinsdottir,Dominiek D. G. Despriet,Sarah Ennis,Sayoko E. Moroi,Nicholas G. Martin,Nomdo M. Jansonius,Seyhan Yazar,E-Shyong Tai,Philippe Amouyel,James F Kirwan,Leonieke M E van Koolwijk,Michael A. Hauser,Fridbert Jonasson,Paul Leo,Stephanie J. Loomis,Rhys Fogarty,Fernando Rivadeneira,Lisa S. Kearns,Karl J. Lackner,Paulus T. V. M. de Jong,Paulus T. V. M. de Jong,Claire L. Simpson,Craig E. Pennell,Ben A. Oostra,André G. Uitterlinden,Seang-Mei Saw,Andrew J. Lotery,Joan E. Bailey-Wilson,Albert Hofman,Johannes R. Vingerling,Cécilia Maubaret,Cécilia Maubaret,Norbert Pfeiffer,Roger C. W. Wolfs,Hans G Lemij,Terri L. Young,Louis R. Pasquale,Louis R. Pasquale,Cécile Delcourt,Cécile Delcourt,Tim D. Spector,Caroline C W Klaver,Kerrin S. Small,Kathryn P. Burdon,Kari Stefansson,Tien Yin Wong,Ananth C. Viswanathan,David A. Mackey,David A. Mackey,Jamie E Craig,Janey L. Wiggs,Cornelia M. van Duijn,Christopher J Hammond,Tin Aung +100 more
TL;DR: The results of a genome-wide association study meta-analysis of 18 population cohorts from the International Glaucoma Genetics Consortium (IGGC), comprising 35,296 multi-ancestry participants for IOP were reported in this article.
Journal ArticleDOI
Directional dominance on stature and cognition in diverse human populations
Peter K. Joshi,Tõnu Esko,Hannele Mattsson,Niina Eklund,Ilaria Gandin,Teresa Nutile,Anne U. Jackson,Claudia Schurmann,Albert V. Smith,Weihua Zhang,Yukinori Okada,Alena Stančáková,Jessica D. Faul,Wei Zhao,Traci M. Bartz,Maria Pina Concas,Nora Franceschini,Stefan Enroth,Veronique Vitart,Stella Trompet,Xiuqing Guo,Daniel I. Chasman,Jeffrey R. O'Connel,Tanguy Corre,Suraj S. Nongmaithem,Yuning Chen,Massimo Mangino,Daniela Ruggiero,Michela Traglia,Aliki-Eleni Farmaki,Tim Kacprowski,Andrew Bjonnes,Ashley van der Spek,Ying Wu,Anil K. Giri,Lisa R. Yanek,Lihua Wang,Edith Hofer,Cornelius A. Rietveld,Olga McLeod,Marilyn C. Cornelis,Cristian Pattaro,Niek Verweij,Clemens Baumbach,Abdel Abdellaoui,Helen R. Warren,Dragana Vuckovic,Hao Mei,Claude Bouchard,John R. B. Perry,Stefania Cappellani,Saira Saeed Mirza,Miles C. Benton,Ulrich Broeckel,Sarah E. Medland,Penelope A. Lind,Giovanni Malerba,Alexander W. Drong,Loic Yengo,Lawrence F. Bielak,Degui Zhi,Peter J. van der Most,Daniel Shriner,Reedik Mägi,Gibran Hemani,Tugce Karaderi,Zhaoming Wang,Tian Liu,Ilja Demuth,Jing Hua Zhao,Weihua Meng,Lazaros Lataniotis,Sander W. van der Laan,Jonathan P. Bradfield,Andrew R. Wood,Amélie Bonnefond,Tarunveer S. Ahluwalia,Leanne M. Hall,Erika Salvi,Seyhan Yazar,Lisbeth Carstensen,Hugoline G. de Haan,Mark Abney,Uzma Afzal,Matthew A. Allison,Najaf Amin,Folkert W. Asselbergs,Stephan J. L. Bakker,R. Graham Barr,Sebastian E. Baumeister,Daniel J. Benjamin,Sven Bergmann,Eric Boerwinkle,Erwin P. Bottinger,Archie Campbell,Aravinda Chakravarti,Yingleong Chan,Stephen J. Chanock,Constance Chen,Y.-D. Ida Chen,Francis S. Collins,John M. C. Connell,Adolfo Correa,L. Adrienne Cupples,George Davey Smith,Gail Davies,Marcus Dörr,Georg Ehret,Stephen B. Ellis,Bjarke Feenstra,Mary F. Feitosa,Ian Ford,Caroline S. Fox,Timothy M. Frayling,Nele Friedrich,Frank Geller,Generation Scotland,Irina Gillham-Nasenya,Omri Gottesman,Misa Graff,Francine Grodstein,Charles Gu,Chris Haley,Christopher J Hammond,Sarah E. Harris,Tamara B. Harris,Nicholas D. Hastie,Nancy L. Heard-Costa,Kauko Heikkilä,Lynne J. Hocking,Georg Homuth,Jouke-Jan Hottenga,Jinyan Huang,Jennifer E. Huffman,Pirro G. Hysi,M. Arfan Ikram,Erik Ingelsson,Anni Joensuu,Åsa Johansson,Pekka Jousilahti,J. Wouter Jukema,Mika Kähönen,Yoichiro Kamatani,Stavroula Kanoni,Shona M. Kerr,Nazir M. Khan,Philipp Koellinger,Heikki A. Koistinen,Manraj K. Kooner,Michiaki Kubo,Johanna Kuusisto,Jari Lahti,Lenore J. Launer,Rodney A. Lea,Benjamin Lehne,Terho Lehtimäki,David C. Liewald,Lars Lind,Marie Loh,Marja-Liisa Lokki,Stephanie J. London,Stephanie J. Loomis,Anu Loukola,Yingchang Lu,Thomas Lumley,Annamari Lundqvist,Satu Männistö,Pedro Marques-Vidal,Corrado Masciullo,Angela Matchan,Rasika A. Mathias,Koichi Matsuda,James B. Meigs,Christa Meisinger,Thomas Meitinger,Cristina Menni,Frank D. Mentch,Evelin Mihailov,Lili Milani,May E. Montasser,Grant W. Montgomery,Alanna C. Morrison,Richard H. Myers,Rajiv Nadukuru,Pau Navarro,Mari Nalis,Markku S. Nieminen,Ilja M. Nolte,George T. O'Connor,Adesola Ogunniyi,Sandosh Padmanabhan,Walter Palmas,James S. Pankow,Inga Patarčić,Francesca Pavani,Patricia A. Peyser,Kirsi H. Pietiläinen,Neil R Poulter,Inga Prokopenko,Sarju Ralhan,Paul Redmond,Stephen S. Rich,Harri Rissanen,Antonietta Robino,Lynda M. Rose,Richard J. Rose,Cinzia Sala,Babatunde L. Salako,Veikko Salomaa,Antti-Pekka Sarin,Richa Saxena,Helena Schmidt,Laura J. Scott,William R. Scott,Bengt Sennblad,Sudha Seshadri,Peter S. Sever,Smeeta Shrestha,Blair H. Smith,Jennifer A. Smith,Nicole Soranzo,Nona Sotoodehnia,Lorraine Southam,Alice Stanton,Maria G. Stathopoulou,Konstantin Strauch,Rona J. Strawbridge,Matthew Suderman,Nikhil Tandon,Sian Tsun Tang,Kent D. Taylor,Bamidele O. Tayo,Anna Maria Töglhofer,Maciej Tomaszewski,Natalia Tšernikova,Jaakko Tuomilehto,André G. Uitterlinden,Dhananjay Vaidya,Astrid van Hylckama Vlieg,Jessica van Setten,Tuula Vasankari,Sailaja Vedantam,Efthymia Vlachopoulou,Diego Vozzi,Eero Vuoksimaa,Melanie Waldenberger,Erin B. Ware,William Wentworth-Shields,John Whitfield,Sarah H. Wild,Gonneke Willemsen,Chittaranjan S. Yajnik,Jie Yao,Gianluigi Zaza,Xiaofeng Zhu,Rany M. Salem,Mads Melbye,Hans Bisgaard,Nilesh J. Samani,Daniele Cusi,David A. Mackey,Richard S. Cooper,Philippe Froguel,Gerard Pasterkamp,Struan F.A. Grant,Hakon Hakonarson,Luigi Ferrucci,Robert A. Scott,Andrew D. Morris,Colin N. A. Palmer,George Dedoussis,Panos Deloukas,Lars Bertram,Ulman Lindenberger,Sonja I. Berndt,Cecilia M. Lindgren,Nicholas J. Timpson,Anke Tönjes,Patricia B. Munroe,Thorkild I. A. Sørensen,Charles N. Rotimi,Donna K. Arnett,Albertine J. Oldehinkel,Sharon L.R. Kardia,Beverley Balkau,Giovanni Gambaro,Andrew P. Morris,Johan G. Eriksson,Margie Wright,Nicholas G. Martin,Steven C. Hunt,John M. Starr,Ian J. Deary,Lyn R. Griffiths,Henning Tiemeier,Nicola Pirastu,Jaakko Kaprio,Nicholas J. Wareham,Louis Pérusse,James G. Wilson,Giorgia Girotto,Mark J. Caulfield,Olli T. Raitakari,Dorret I. Boomsma,Christian Gieger,Pim van der Harst,Andrew A. Hicks,Peter Kraft,Juha Sinisalo,Paul Knekt,Magnus Johannesson,Patrik K. E. Magnusson,Anders Hamsten,Reinhold Schmidt,Ingrid B. Borecki,Erkki Vartiainen,Diane M. Becker,Dwaipayan Bharadwaj,Karen L. Mohlke,Michael Boehnke,Cornelia M. van Duijn,Dharambir K. Sanghera,Alexander Teumer,Eleftheria Zeggini,Andres Metspalu,Paolo Gasparini,Sheila Ulivi,Carole Ober,Daniela Toniolo,Igor Rudan,David J. Porteous,Marina Ciullo,Tim D. Spector,Caroline Hayward,Josée Dupuis,Ruth J. F. Loos,Alan F. Wright,Giriraj R. Chandak,Peter Vollenweider,Alan R. Shuldiner,Paul M. Ridker,Jerome I. Rotter,Naveed Sattar,Ulf Gyllensten,Kari E. North,Mario Pirastu,Bruce M. Psaty,David R. Weir,Markku Laakso,Vilmundur Gudnason,Atsushi Takahashi,John C. Chambers,Jaspal S. Kooner,David P. Strachan,Harry Campbell,Joel N. Hirschhorn,Markus Perola,Ozren Polasek,James F. Wilson +358 more
TL;DR: This study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been.