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Sezgin Bakırdere

Bio: Sezgin Bakırdere is an academic researcher from Turkish Academy of Sciences. The author has contributed to research in topics: Detection limit & Extraction (chemistry). The author has an hindex of 25, co-authored 259 publications receiving 2395 citations. Previous affiliations of Sezgin Bakırdere include National Research Council & Fırat University.


Papers
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TL;DR: Lead analyses showed that there was a considerable contamination in both soil and plants affected from traffic intensity, and overall level of Cd in soil samples lies between 78 and 527 ng/g while cadmium concentration in different vegetations varied in the range of 0.8–98.0 ng g−1.
Abstract: The concentrations of lead, cadmium and copper in roadside soil and plants in Elazig, Turkey were investigated. Soil samples were collected at distances of 0, 25 and 50 m from the roadside. The concentrations of lead, cadmium and copper were measured by Flame Atomic Absorption Spectrophotometry (FAAS). A slotted tube atom trap (STAT) was used to increase the sensitivity of lead and cadmium in FAAS. Lead concentrations in soil samples varied from 1.3 to 45 mg kg(-1) while mean lead levels in plants ranged from120 ng g(-1) for grape in point-4 to 866 ng g(-1) for apple leaves in point-2. Lead analyses showed that there was a considerable contamination in both soil and plants affected from traffic intensity. Overall level of Cd in soil samples lies between 78 and 527 ng/g while cadmium concentration in different vegetations varied in the range of 0.8-98.0 ng g(-1). Concentrations of copper in soil and plant samples were found in the range of 11.1-27.9 mg kg(-1) for soil and 0.8-5.6 mg kg(-1) for plants. Standard reference material (SRM) was used to find the accuracy of the results of soil analyses.

149 citations

Journal ArticleDOI
TL;DR: The concentrations of calcium and zinc in the malign human prostate were found to be significantly higher than those in the benign human prostate (p < 0.05 for both metals), and more studies are needed regarding the increase or decrease in the metal concentrations of malign prostate samples.
Abstract: Imbalance in the composition of trace metals, recognized to be essential to normal human homeostasis, besides the accumulation of potentially toxic or nonessential trace metals, may cause disease. Thus, there is a need for their analysis in cancerous and noncancerous human tissues to examine the relationship between cancer and these elements. Trace metal concentrations including Cd, Ni, Zn, Cu, Fe, Mg, and Ca in both malign and benign prostate samples were determined by atomic absorption spectrophotometry. The tissues were digested by using microwave energy. In contrast to the literature data for zinc, the concentrations of calcium and zinc in the malign human prostate were found to be significantly higher than those in the benign human prostate (p < 0.05 for both metals). Similarly, the concentrations of iron, nickel, and magnesium in the malign prostate were also found to be higher than those in the benign prostate (p

99 citations

Journal ArticleDOI
TL;DR: It is suggested that ingestion of boron in the drinking water decreases the incidence of cervical cancer‐related histopathological findings, and these findings should be validated by other researchers.
Abstract: Recent evidence indicates that boron and borates may have anticarcinogenic properties. In this study, we have investigated the incidence of adverse cytological findings in cervical smears and the micronucleus (MN) frequency in women living in boron-rich and boron-poor regions. Cervical smears were prepared from 1059 women with low socioeconomic status; 472 of the women lived in relatively boron-rich rural areas, while 587 lived in relatively boron-poor regions. The average and standard deviation values for the age of the women screened with the cervical Pap smear test were 41.55 +/- 8.38. The mean dietary intake of boron was 8.41 mg/day for women from the boron-rich regions, and 1.26 mg/day for women living in the boron-poor regions (P 0.05). Also, there were no significant correlations between age and MN frequency for women from both the boron-rich (r = 0.133, P = 0.48, P > 0.05) and boron-poor (r = -0.033, P = 0.861, P > 0.05) regions. The results suggest that ingestion of boron in the drinking water decreases the incidence of cervical cancer-related histopathological findings. There was no correlation between the pathological findings from the cervical smears and buccal cell MN frequency suggesting that the two study populations were exposed equally to gentotoxic agents. Nonetheless, cervical cancer-related histopathological findings should be validated by other researchers.

85 citations

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TL;DR: In this paper, the 24-h composite samples were analyzed in influents and effluents of 7 full scale biological treatment plants of various modifications of activated sludge process, including one MBR plant.

81 citations

Journal ArticleDOI
TL;DR: The types of auto-inducers involved in quorum sensing are described and the fields of study they greatly affect especially the environmental one, which covers types of analytical sample preparation and detection methods, and different types of inhibitors used for quorum quenching.
Abstract: The bacterial communication through signaling molecules termed quorum sensing has gained a lot of attention due to its applicability to different fields of study. Quorum sensing regulates several bacterial activities such as biofilm formation, antibiotic resistance, bioluminescence and bacterial virulence. These coordinated activities are only realized when the bacterial population reaches a high population density. The signaling molecules used in quorum sensing occur at very low concentrations which call for very sensitive methods for their identification and characterization. Many studies have been performed on the use of inhibitors in attempt to disrupt quorum sensing and consequently alleviate its negative effects. This article gives a description of the types of auto-inducers involved in quorum sensing and the fields of study they greatly affect especially the environmental one. It also covers types of analytical sample preparation and detection methods, and different types of inhibitors used for quorum quenching.

76 citations


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01 Jan 2016

1,664 citations

Journal ArticleDOI
01 Jan 2008-Analyst
TL;DR: This review uses evidence from the literature to consider the usefulness and limitations of sequential extraction, and discusses typical applications from the recent literature for which sequential extraction can provide useful and meaningful information.
Abstract: Since their introduction in the late 1970s, sequential extraction procedures have experienced a rapid increase in use. They are now applied for a large number of potentially toxic elements in a wide range of sample types. This review uses evidence from the literature to consider the usefulness and limitations of sequential extraction and thereby to assess its future role in environmental chemical analysis. It is not the intention to provide a comprehensive survey of all applications of sequential extractions or to consider the merits and disadvantages of individual schemes. These aspects have been covered adequately in other, recent reviews. This review focuses in particular on various key issues surrounding sequential extractions such as nomenclature, methodologies, presentation of data and interpretation of data, and discusses typical applications from the recent literature for which sequential extraction can provide useful and meaningful information. Also covered are emerging developments such as accelerated procedures using ultrasound- or microwave energy-assisted extractions, dynamic extractions, the use of chemometrics, the combination of sequential extraction with isotope analysis, and the extension of the approach to non-traditional analytes such as arsenic, mercury, selenium and radionuclides.

554 citations

Journal ArticleDOI
TL;DR: The harmonization and standardization of the buccal MN assay will allow more reliable comparison of the data among human populations and laboratories, evaluation of the assay's performance, and consolidation of its world-wide use for biomonitoring of DNA damage.
Abstract: The micronucleus (MN) assay in exfoliated buccal cells is a useful and minimally invasive method for monitoring genetic damage in humans. This overview has concluded that although MN assay in buccal cells has been used since the 1980s to demonstrate cytogenetic effects of environmental and occupational exposures, lifestyle factors, dietary deficiencies, and different diseases, important knowledge gaps remain about the characteristics of micronuclei and other nuclear abnormalities, the basic biology explaining the appearance of various cell types in buccal mucosa samples and effects of diverse staining procedures and scoring criteria in laboratories around the world. To address these uncertainties, the human micronucleus project (HUMN; see http://www.humn.org) has initiated a new international validation project for the buccal cell MN assay similar to that previously performed using human lymphocytes. Future research should explore sources of variability in the assay (e.g. between laboratories and scorers, as well as inter- and intra-individual differences in subjects), and resolve key technical issues, such as the method of buccal cell staining, optimal criteria for classification of normal and degenerated cells and for scoring micronuclei and other abnormalities. The harmonization and standardization of the buccal MN assay will allow more reliable comparison of the data among human populations and laboratories, evaluation of the assay's performance, and consolidation of its world-wide use for biomonitoring of DNA damage.

512 citations

Yang, Zhang, Chen, Zhuang, Xu, Wang 
01 Jan 2007
TL;DR: Experiments have proved that these catalysts have a long-term stability toward temperature and pH change, as compared to free enzyme molecules and a magnetic-separation immunoassay system was developed for the quantitative determination of gentamicin.
Abstract: The simultaneous entrapment of biological macromolecules and nanostructured silica-coated magnetite in sol-gel materials using a reverse-micelle technique leads to a bioactive, mechanically stable, nanometer-sized, and magnetically separable particles. These spherical particles have a typical diameter of 53 +/- 4 nm, a large surface area of 330 m(2)/g, an average pore diameter of 1.5 nm, a total pore volume of 1.427 cm(3)/g and a saturated magnetization (M(S)) of 3.2 emu/g. Peroxidase entrapped in these particles shows Michaelis-Mentan kinetics and high activity. The catalytic reaction will take place immediately after adding these particles to the reaction solution. These enzyme entrapping particles catalysts can be easily separated from the reaction mixture by simply using an external magnetic field. Experiments have proved that these catalysts have a long-term stability toward temperature and pH change, as compared to free enzyme molecules. To further prove the application of this novel magnetic biomaterial in analytical chemistry, a magnetic-separation immunoassay system was also developed for the quantitative determination of gentamicin. The calibration for gentamicin has a working range of 200-4000 ng/mL, with a detection limit of 160 ng/mL, which is close to that of the fluorescent polarization immunoassay (FPIA) using the same reactants.

464 citations

Journal ArticleDOI
TL;DR: Technological solutions including conventional activated sludge, membrane bioreactors, moving bed biofilm reactors, and nature-based solutions such as constructed wetlands are compared for the achievable removal efficiencies of the selected CEC and their potential of acting as reservoirs of ARB&ARGs.

312 citations