Shaban A. Khaled

TL;DR: 3D extrusion printing was used to manufacture a multi-active solid dosage form that showed the intended immediate and sustained release profiles based upon the active/excipient ratio used and demonstrates that complex medication regimes can be combined in a single personalised tablet.

TL;DR: The printed formulations were evaluated for physical and mechanical properties such as weight variation, friability, hardness and thickness as a comparison to the commercial tablet and were within acceptable range as defined by the international standards stated in the United States Pharmacopoeia (USP).

TL;DR: This 'polypill' made by a 3D additive manufacture technique demonstrates that complex medication regimes can be combined in a single tablet and that it is viable to formulate and 'dial up' this single tablet for the particular needs of an individual.

TL;DR: The manufacture of immediate release high drug loading paracetamol oral tablets was achieved using an extrusion based 3D printer from a premixed water based paste formulation and showed a profile characteristic of the immediate release profile as intended based upon the active/excipient ratio.

TL;DR: The ability to use a single unmodified formulation to achieve defined release profiles could allow, for example, relatively straightforward personalization of medicines for individuals with different metabolism rates for certain drugs and hence could offer significant development and clinical opportunities.