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Shahaf Peleg
Researcher at Leibniz Association
Publications - 22
Citations - 1422
Shahaf Peleg is an academic researcher from Leibniz Association. The author has contributed to research in topics: Histone & Biology. The author has an hindex of 8, co-authored 16 publications receiving 1205 citations. Previous affiliations of Shahaf Peleg include Qingdao University & Center for Integrated Protein Science Munich.
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Journal ArticleDOI
Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice
Shahaf Peleg,Farahnaz Sananbenesi,Athanasios Zovoilis,Susanne Burkhardt,Sanaz Bahari-Javan,Roberto Carlos Agis-Balboa,Perla Cota,Jessica Wittnam,Andreas Gogol-Doering,Lennart Opitz,Gabriella Salinas-Riester,Markus Dettenhofer,Hui Kang,Laurent Farinelli,Wei Chen,Andre Fischer +15 more
TL;DR: It is shown that memory disturbances in the aging brain of the mouse are associated with altered hippocampal chromatin plasticity, and data suggest that deregulated H4K12 acetylation may represent an early biomarker of an impaired genome-environment interaction in the Aging mouse brain.
Journal ArticleDOI
Circadian acetylome reveals regulation of mitochondrial metabolic pathways
Selma Masri,Vishal R. Patel,Kristin Eckel-Mahan,Shahaf Peleg,Ignasi Forné,Andreas G. Ladurner,Pierre Baldi,Axel Imhof,Paolo Sassone-Corsi +8 more
TL;DR: The acetylome is characterized and changes in enzyme acetylation over the circadian cycle and the link to metabolite levels are discussed, revealing biological implications connecting the circadian clock to cellular metabolic state.
Journal ArticleDOI
The Metabolic Impact on Histone Acetylation and Transcription in Ageing
TL;DR: Experimental data supporting connections between aging and histone acetylation patterns and key metabolites such as acetyl-CoA and NAD(+) are discussed and a context for the possible medical and physiological relevance is provided.
Journal ArticleDOI
Life span extension by targeting a link between metabolism and histone acetylation in Drosophila
Shahaf Peleg,Christian Feller,Ignasi Forné,Ignasi Forné,Evelyn Schiller,Daniel C. Sévin,Tamas Schauer,Catherine Regnard,Tobias Straub,Tobias Straub,Matthias Prestel,Caroline Klima,Melanie Schmitt Nogueira,Lore Becker,Thomas Klopstock,Thomas Klopstock,Uwe Sauer,Peter B. Becker,Axel Imhof,Axel Imhof,Andreas G. Ladurner +20 more
TL;DR: A pathway that couples changes of intermediate metabolism during aging with the chromatin‐mediated regulation of transcription and changes in the activity of associated enzymes that modulate organismal life span is revealed.
Journal ArticleDOI
Distinct metabolic adaptation of liver circadian pathways to acute and chronic patterns of alcohol intake
Jonathan Gaucher,Kenichiro Kinouchi,Nicholas Ceglia,Emilie Montellier,Shahaf Peleg,Carolina Magdalen Greco,Andreas Schmidt,Ignasi Forné,Selma Masri,Pierre Baldi,Axel Imhof,Paolo Sassone-Corsi +11 more
TL;DR: It is revealed that distinct patterns of alcohol consumption differentially reprogram circadian gene expression in the liver, and rewiring of circadian SREBP pathways impacts subcellular partitioning of protein acetylation through acetyl-CoA metabolism, which dictates differential adaptation of hepatic circadian metabolism.