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Shakib Omari

Researcher at National Institutes of Health

Publications -  11
Citations -  1915

Shakib Omari is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Procollagen peptidase & Golgi apparatus. The author has an hindex of 8, co-authored 10 publications receiving 920 citations. Previous affiliations of Shakib Omari include Discovery Institute & Howard Hughes Medical Institute.

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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
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Foxl2 is required for commitment to ovary differentiation

TL;DR: It is found that mouse XX gonads lacking the forkhead transcription factor Foxl2 form meiotic prophase oocytes, but then activate the genetic program for somatic testis determination, suggesting the possible continued involvement of sex-determining genes in maintaining ovarian function throughout female reproductive life.
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Noncanonical autophagy at ER exit sites regulates procollagen turnover.

TL;DR: Overall, the findings reveal that a subset of procollagen molecules is directed toward lysosomal degradation through an autophagic pathway originating at ERESs, providing a mechanism to remove excess Procollagen from cells.
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Foxl2 functions in sex determination and histogenesis throughout mouse ovary development

TL;DR: In the absence of Foxl2, expression changes affecting a large fraction of pathways were opposite those observed in Wnt4-null ovaries, reinforcing the notion that these genes have complementary actions in ovary development.
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Constitutively active Foxo3 in oocytes preserves ovarian reserve in mice.

TL;DR: This is the first gain-of-function model of augmented reproductive reserve in mice, thus emphasizing the role of Foxo3 as a guardian of the ovarian follicle pool in mammals and a potential determinant of the onset of menopause.