S
Shalini Agarwal
Researcher at Jawaharlal Nehru University
Publications - 13
Citations - 258
Shalini Agarwal is an academic researcher from Jawaharlal Nehru University. The author has contributed to research in topics: Entamoeba histolytica & Plasmodium falciparum. The author has an hindex of 8, co-authored 13 publications receiving 199 citations. Previous affiliations of Shalini Agarwal include International Centre for Genetic Engineering and Biotechnology.
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Journal ArticleDOI
Calcium-dependent permeabilization of erythrocytes by a perforin-like protein during egress of malaria parasites.
Swati Garg,Shalini Agarwal,Saravanan Kumar,Syed Shams Yazdani,Chetan E. Chitnis,Shailja Singh,Shailja Singh +6 more
TL;DR: It is demonstrated that calcium-dependent permeabilization of host red blood cells is critical for egress of Plasmodium falciparum merozoites.
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Ca(2+) -mediated exocytosis of subtilisin-like protease 1: a key step in egress of Plasmodium falciparum merozoites.
TL;DR: The role of intracellular Ca2+ in regulation of egress of P. falciparum merozoites from schizonts is tested and novel targets for development of drugs that block egress and limit parasite growth are identified.
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Calcium-dependent phosphorylation of Plasmodium falciparum serine repeat antigen 5 triggers merozoite egress.
Gayatri R. Iyer,Shailja Singh,Shailja Singh,Inderjeet Kaur,Shalini Agarwal,Mansoor A. Siddiqui,Abhisheka Bansal,Gautam Kumar,Ekta Saini,Gourab Paul,Asif Mohmmed,Chetan E. Chitnis,Chetan E. Chitnis,Pawan Malhotra +13 more
TL;DR: It is suggested that phosphorylation of PfSERA5 by PfCDPK1 following a rise in cytosolic Ca2+ levels activates its proteolytic activity to trigger merozoite egress.
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Natural Product Inspired Novel Indole based Chiral Scaffold Kills Human Malaria Parasites via Ionic Imbalance Mediated Cell Death.
Poonam Dangi,Ravi Jain,Rajanikanth Mamidala,Vijeta Sharma,Shalini Agarwal,Chandramohan Bathula,M. Thirumalachary,Subhabrata Sen,Shailja Singh,Shailja Singh +9 more
TL;DR: It is shown that ionic imbalance caused by scaffold 7 induces autophagy that leads to onset of apoptosis in the parasite evident by the loss of mitochondrial membrane potential (ΔΨm) and DNA degradation.
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EhP3, a homolog of 14-3-3 family of protein participates in actin reorganization and phagocytosis in Entamoeba histolytica.
Shalini Agarwal,Gaurav Anand,Shalini Sharma,Pragyan Parimita Rath,Samudrala Gourinath,Alok Bhattacharya +5 more
TL;DR: The findings strongly suggest that EhP3 is a novel and a key regulatory element of actin dynamics and phagocytosis in E. histolytica, the etiological agent of human amebiasis.