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Shang Yu Gong
Researcher at McGill University
Publications - 27
Citations - 662
Shang Yu Gong is an academic researcher from McGill University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 5, co-authored 14 publications receiving 149 citations.
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Journal ArticleDOI
A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responses.
Alexandra Tauzin,Manon Nayrac,Mehdi Benlarbi,Shang Yu Gong,Romain Gasser,Guillaume Beaudoin-Bussières,Nathalie Brassard,Annemarie Laumaea,Dani Vézina,Jérémie Prévost,Sai Priya Anand,Catherine Bourassa,Gabrielle Gendron-Lepage,Halima Medjahed,Guillaume Goyette,Julia Niessl,Olivier Tastet,Laurie Gokool,Chantal Morrisseau,Pascale Arlotto,Leonidas Stamatatos,Leonidas Stamatatos,Andrew T. McGuire,Catherine Larochelle,Pradeep D. Uchil,Maolin Lu,Walther Mothes,Gaston De Serres,Sandrine Moreira,Michel Roger,Jonathan Richard,Valérie Martel-Laferrière,Ralf Duerr,Cécile Tremblay,Daniel Kaufmann,Andrés Finzi,Andrés Finzi +36 more
TL;DR: In this article, a single dose of the BNT162b2 mRNA vaccine for SARS-CoV-2 was found to be up to 90% effective starting 14 days post-administration.
Journal ArticleDOI
Longitudinal analysis of humoral immunity against SARS-CoV-2 Spike in convalescent individuals up to 8 months post-symptom onset.
Sai Priya Anand,Jérémie Prévost,Manon Nayrac,Guillaume Beaudoin-Bussières,Mehdi Benlarbi,Romain Gasser,Nathalie Brassard,Annemarie Laumaea,Shang Yu Gong,Catherine Bourassa,Elsa Brunet-Ratnasingham,Halima Medjahed,Gabrielle Gendron-Lepage,Guillaume Goyette,Laurie Gokool,Chantal Morrisseau,Philippe Bégin,Valérie Martel-Laferrière,Cécile Tremblay,Jonathan Richard,Renée Bazin,Ralf Duerr,Daniel Kaufmann,Andrés Finzi,Andrés Finzi +24 more
TL;DR: In this article, the presence of SARS-CoV-2-specific memory B cells in convalescent individuals was evaluated using a longitudinal assessment of humoral immune responses.
Journal ArticleDOI
A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection
Guillaume Beaudoin-Bussières,Yaozong Chen,Irfan Ullah,Jérémie Prévost,William D. Tolbert,Kelly Symmes,Shilei Ding,Mehdi Benlarbi,Shang Yu Gong,Alexandra S. Tauzin,Romain Gasser,Debashree Chatterjee,Dani Vézina,Guillaume Goyette,Jonathan Richard,Fei Zhou,Leonidas Stamatatos,Andrew T. McGuire,Hughes Charest,Michel Roger,Edwin Pozharski,Priti Kumar,Walther Mothes,Pradeep D. Uchil,Marzena Pazgier,Andrés Finzi +25 more
TL;DR: In this article , a non-neutralizing antibody, CV3-13, was isolated from a convalescent individual with potent Fc-mediated effector functions, and the antibody binds from a distinct angle of approach to an N-terminal domain (NTD) epitope that only partially overlaps with the NTD supersite recognized by neutralizing antibodies.
Journal ArticleDOI
Contribution of single mutations to selected SARS-CoV-2 emerging variants spike antigenicity.
Shang Yu Gong,Debashree Chatterjee,Jonathan Richard,Jérémie Prévost,Alexandra Tauzin,Romain Gasser,Yuxia Bo,Dani Vézina,Guillaume Goyette,Gabrielle Gendron-Lepage,Halima Medjahed,Michel Roger,Marceline Côté,Andrés Finzi,Andrés Finzi +14 more
TL;DR: In this paper, the impact of single mutations on the overall antigenicity of selected variants and their binding to the ACE2 receptor was evaluated using biolayer interferometry, and it was shown that enhanced ACE2 interaction is mostly modulated by a decrease in off-rate.
Posted ContentDOI
Longitudinal analysis of humoral immunity against SARS-CoV-2 Spike in convalescent individuals up to 8 months post-symptom onset
Sai Priya Anand,Jérémie Prévost,Manon Nayrac,Guillaume Beaudoin-Bussières,Mehdi Benlarbi,Romain Gasser,Nathalie Brassard,Annemarie Laumaea,Shang Yu Gong,Catherine Bourassa,Elsa Brunet-Ratnasingham,Halima Medjahed,Gabrielle Gendron-Lepage,Guillaume Goyette,Laurie Gokool,Chantal Morrisseau,Philippe Bégin,Valérie Martel-Laferrière,Cécile Tremblay,Jonathan Richard,Renée Bazin,Ralf Duerr,Daniel Kaufmann,Andrés Finzi,Andrés Finzi +24 more
TL;DR: In this article, the evolution of the overall humoral immune responses on 101 blood samples obtained from 32 COVID-19 convalescent patients between 16 and 233 days post-symptom onset was investigated.