Shannon K. Bromley

TL;DR: Immunological synapse formation is now shown to be an active and dynamic mechanism that allows T cells to distinguish potential antigenic ligands and was a determinative event for T cell proliferation.

TL;DR: The current model is that signaling and formation of the immunological synapse are tightly interwoven in mature T cells and this model is extended to natural killer cell activation, where the inhibitory NK synapse provides a striking example in which inhibition of signaling leaves the synapse in its nascent, inverted state.

TL;DR: It is demonstrated that ligand engagement of the adhesion molecule, CD2, initiates a process of protein segregation,CD2 clustering, and cytoskeletal polarization that is likely to facilitate receptor patterning in the contact area by linking specific adhesion receptors to the cytoskeleton.

TL;DR: Advances in understanding of how chemokines orchestrate the trafficking and activity of immune cells has increased considerably are reviewed with particular emphasis on control of the migration of T cell subsets in lymph nodes and in peripheral tissues in homeostasis and inflammation.

TL;DR: This study establishes a molecular basis for T cell exit from peripheral tissues by demonstrating that the chemokine receptor CCR7 is a critical signal that determines T cellexit from peripheral tissue.