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Shanshan W. Howland
Researcher at Agency for Science, Technology and Research
Publications - 40
Citations - 1702
Shanshan W. Howland is an academic researcher from Agency for Science, Technology and Research. The author has contributed to research in topics: Cytotoxic T cell & Antigen. The author has an hindex of 15, co-authored 36 publications receiving 1293 citations. Previous affiliations of Shanshan W. Howland include Massachusetts Institute of Technology & Singapore Immunology Network.
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Journal ArticleDOI
Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells.
Charles-Antoine Dutertre,Charles-Antoine Dutertre,Etienne Becht,Sergio Erdal Irac,Sergio Erdal Irac,Ahad Khalilnezhad,Ahad Khalilnezhad,Vipin Narang,Shabnam Khalilnezhad,Pei Y. Ng,Lucas L van den Hoogen,Jing Yao Leong,Bernett Lee,Marion Chevrier,Xiao Meng Zhang,Pearly Yong,Geraldine Koh,Josephine Lum,Shanshan W. Howland,Esther Wing Hei Mok,Jinmiao Chen,Anis Larbi,Henry K.K. Tan,Tony Kiat Hon Lim,Panagiota Karagianni,Athanasios G. Tzioufas,Benoit Malleret,Benoit Malleret,Joshua Brody,Salvatore Albani,Joel A G van Roon,Timothy R D J Radstake,Evan W. Newell,Florent Ginhoux,Florent Ginhoux +34 more
TL;DR: High-dimensional single-cell protein and RNA expression data is integrated to identify distinct markers to delineate monocytes from conventional DC2 (cDC2s), further unravel the heterogeneity of DC subpopulations in health and disease and may pave the way for the identification of specific DC subset-targeting therapies.
Journal ArticleDOI
A rapid and robust tri-color flow cytometry assay for monitoring malaria parasite development
Benoit Malleret,Carla Claser,Alice Soh Meoy Ong,Rossarin Suwanarusk,Kanlaya Sriprawat,Shanshan W. Howland,Bruce Russell,François Nosten,François Nosten,Laurent Rénia +9 more
TL;DR: A fast and simple flow cytometry method to quantify and stage, various malaria parasites in red blood cells in whole blood or in vitro cultured Plasmodium falciparum is developed and demonstrated how this technique can be applied to antimalarial drug testing.
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CD8+ T cells and IFN-γ mediate the time-dependent accumulation of infected red blood cells in deep organs during experimental cerebral malaria.
Carla Claser,Benoit Malleret,Sin Yee Gun,Alicia Yoke Wei Wong,Zi Wei Chang,Pearline Teo,Peter See,Shanshan W. Howland,Florent Ginhoux,Laurent Rénia +9 more
TL;DR: CD8+ T cells and IFN-γ are the major immune mediators controlling the time-dependent accumulation of P. berghei-infected red blood cells in tissues.
Journal ArticleDOI
Brain microvessel cross-presentation is a hallmark of experimental cerebral malaria
Shanshan W. Howland,Chek Meng Poh,Chek Meng Poh,Sin Yee Gun,Sin Yee Gun,Carla Claser,Benoit Malleret,Nilabh Shastri,Florent Ginhoux,Gijsbert M. Grotenbreg,Laurent Rénia,Laurent Rénia +11 more
TL;DR: It is demonstrated here that PbA infection causes brain microvessels to cross‐present parasite antigen, while non‐ECM‐causing parasites do not, and combined therapies targeting both the parasite and host antigen‐presenting cells may improve the outcome of CM patients.
Journal ArticleDOI
Cerebral malaria: Mysteries at the blood-brain barrier
Laurent Rénia,Shanshan W. Howland,Carla Claser,Anne Charlotte Grüner,Rossarin Suwanarusk,Teck Hui Teo,Bruce Russell,Lisa F. P. Ng +7 more
TL;DR: The most recent findings from human studies and mouse models on the interactions of malaria parasites and the blood-brain barrier are reviewed, shedding light on the pathogenesis of cerebral malaria, which may provide directions for possible interventions.