Author
Shantini Saminathan
Other affiliations: Royal Institute of Technology
Bio: Shantini Saminathan is an academic researcher from University of Peradeniya. The author has contributed to research in topics: Michelia. The author has an hindex of 1, co-authored 1 publications receiving 62 citations. Previous affiliations of Shantini Saminathan include Royal Institute of Technology.
Topics: Michelia
Papers
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TL;DR: In this paper, five sesquiterpene lactones were isolated from Michelia champaca root bark, including michampanolide (2.7-dihydroxy-3,7-dimethyl-11-methylene-13-oxatricyclo[8,3,0, 0, 0.3, 3,7,b]tridecan-12-one), which possessed a new skeleton, while two others, 8-acetoxyparthenolide and magnograndiolide, were isolated for the
69 citations
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TL;DR: This review of available literature from four Swiss university libraries, scientific journals and online database query's on plants and remedies used in traditional medicinal systems for such diseases relevant to dementia and Alzheimer's disease found over 150 plant species in various preparations and mixtures.
276 citations
TL;DR: It is reported that natural GSL compounds arglabin, an anticancer clinical drug, and micheliolide (MCL), are able to reduce the proportion of AML stem cells (CD34⁺CD38⁻) in primary AML cells and that GSL is potentially highly useful to explore anti-CSC approaches.
Abstract: Small molecules that can selectively target cancer stem cells (CSCs) remain rare currently and exhibit no common structural features. Here we report a series of guaianolide sesquiterpene lactones (GSLs) and their derivatives that can selectively eradicate acute myelogenous leukemia (AML) stem or progenitor cells. Natural GSL compounds arglabin, an anticancer clinical drug, and micheliolide (MCL), are able to reduce the proportion of AML stem cells (CD34+CD38–) in primary AML cells. Targeting of AML stem cells is further confirmed by a sharp reduction of colony-forming units of primary AML cells upon MCL treatment. Moreover, DMAMCL, the dimethylamino Michael adduct of MCL, slowly releases MCL in plasma and in vivo and demonstrates remarkable therapeutic efficacy in the nonobese diabetic/severe combined immunodeficiency AML models. These findings indicate that GSL is an ample source for chemical agents against AML stem or progenitor cells and that GSL is potentially highly useful to explore anti-CSC approaches.
159 citations
TL;DR: Compounds 1-8 are potential cytotoxic agents but without significant antibacterial effect, and the structures of the new compounds were elucidated from spectroscopic and/or X-ray data interpretations.
Abstract: Bioassay-directed fractionation of Saussurea lappa led to the isolation of a novel lappadilactone (1) and seven sesquiterpene lactones (2-8) as cytotoxic principles against selected human cancer cell lines. Lappadilactone (1), dehydrocostuslactone (2), and costunolide (5) exhibited the most potent cytotoxicity with CD50 values in the range 1.6-3.5 microg/mL in dose- and time-dependent manners. The cytotoxicities were not specific and showed similar activities against HepG2, OVCAR-3 and HeLa cell lines. The structure-activity relationship showed that the alpha-methylene-gamma-lactone moiety is necessary for cytotoxicity, and activity is reduced with the presence of a hydroxyl group. In addition, seven noncytotoxic compounds (9-15) were also isolated, including two novel sesquiterpenes, a guaianolide-type with a C17 skeleton, lappalone (13), and 1beta,6alpha-dihydroxycostic acid ethyl ester (14). The structures of the new compounds were elucidated from spectroscopic and/or X-ray data interpretations. Some representative compounds were also tested for antibacterial activity; however, only marginal activities were observed. Therefore, compounds 1-8 are potential cytotoxic agents but without significant antibacterial effect.
134 citations
TL;DR: The plant species screened in this research was recorded by several indigenous medicinal practitioners as antiparasitic, anticancer and/or related activities to the human major organ system.
108 citations
TL;DR: Fractionation drastically enhanced the level of activity in all fractions of the stem bark and dichloromethane fraction of the root bark, and Liriodenine was the active constituent of theroot bark, with a broader and, in some cases, betterlevel of activity as compared to the standard.
73 citations