S
Sharat Sarmah
Researcher at National Institute of Technology, Meghalaya
Publications - 13
Citations - 455
Sharat Sarmah is an academic researcher from National Institute of Technology, Meghalaya. The author has contributed to research in topics: Quenching (fluorescence) & Glycation. The author has an hindex of 5, co-authored 9 publications receiving 253 citations.
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An investigation into the identification of potential inhibitors of SARS-CoV-2 main protease using molecular docking study.
TL;DR: Rutin ( a natural compound) has the highest inhibitor efficiency among the 33 molecules studied, followed by ritonavir (control drug), emetine (anti-protozoal), hesperidin (a natural compound), lopinavir ( control drug) and indinavir(anti-viral drug).
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Exploring the interaction of bioactive kaempferol with serum albumin, lysozyme and hemoglobin: A biophysical investigation using multi-spectroscopic, docking and molecular dynamics simulation studies.
Sourav Das,Zaved Hazarika,Sharat Sarmah,Kakali Baruah,Mostofa Ataur Rohman,Debojit Paul,Anupam Nath Jha,Atanu Singha Roy +7 more
TL;DR: The ligand, KMP was able to quench the intrinsic fluorescence of these three proteins efficiently through static quenching mode and alter the micro-environment near the Trp fluorophore of the proteins.
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Targeting the heme protein hemoglobin by (-)-epigallocatechin gallate and the study of polyphenol-protein association using multi-spectroscopic and computational methods.
Sourav Das,Sharat Sarmah,Zaved Hazarika,Mostofa Ataur Rohman,Pallavi Sarkhel,Anupam Nath Jha,Atanu Singha Roy +6 more
TL;DR: EGCG was found to prevent the glyoxal (GO)-mediated glycation process of BHb, and it was also found to act as a potent antioxidant against the photo-oxidative damage of Bhb.
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Lysozyme-luteolin binding: molecular insights into the complexation process and the inhibitory effects of luteolin towards protein modification.
Sourav Das,Somdev Pahari,Sharat Sarmah,Mostofa Ataur Rohman,Debojit Paul,Madhurima Jana,Atanu Singha Roy +6 more
TL;DR: Luteolin showed promising inhibitory effects towards the d-ribose mediated glycation of HEWL as well as towards HewL fibrillation as studied by fluorescence emission and imaging studies.
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Elucidation of molecular interaction of bioactive flavonoid luteolin with human serum albumin and its glycated analogue using multi-spectroscopic and computational studies
TL;DR: Information is gathered to give a better understanding of the functional changes occurred due to structural modification of HSA induced by glycation and may have some useful impact on the field of pharmaceutical sciences.