S
Sharath Kumar Anand
Researcher at Wayne State University
Publications - 19
Citations - 364
Sharath Kumar Anand is an academic researcher from Wayne State University. The author has contributed to research in topics: Medicine & Hydrocephalus. The author has an hindex of 4, co-authored 14 publications receiving 210 citations. Previous affiliations of Sharath Kumar Anand include University of Michigan.
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Journal ArticleDOI
Cellular and Genetic Causes of Idiopathic Hyperaldosteronism
Kei Omata,Fumitoshi Satoh,Ryo Morimoto,Sadayoshi Ito,Yuto Yamazaki,Yasuhiro Nakamura,Yasuhiro Nakamura,Sharath Kumar Anand,Zeng Guo,Michael Stowasser,Hironobu Sasano,Scott A. Tomlins,William E. Rainey +12 more
TL;DR: IHA may result from not only hyperplasia but also the accumulation or enlargement of computed tomography-undetectable APCC harboring somatic aldosterone-driver gene mutations, and the high prevalence of mutations in the CACNA1D L-type calcium channel provides a potential actionable therapeutic target.
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Aldosterone-Producing Cell Clusters Frequently Harbor Somatic Mutations and Accumulate With Age in Normal Adrenals.
Kei Omata,Kei Omata,Sharath Kumar Anand,Daniel H. Hovelson,Chia Jen Liu,Yuto Yamazaki,Yasuhiro Nakamura,Sadayoshi Ito,Fumitoshi Satoh,Hironobu Sasano,William E. Rainey,Scott A. Tomlins +11 more
TL;DR: APCCs are frequent in nonhypertensive Japanese adrenals, accumulate with age, and frequently harbor somatic mutations (most commonly in CACNA1D).
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Role and regulation of coordinately expressed de novo purine biosynthetic enzymes PPAT and PAICS in lung cancer
Moloy T. Goswami,Guoan Chen,Balabhadrapatruni V. S. K. Chakravarthi,Satya Pathi,Sharath Kumar Anand,Shannon Carskadon,Thomas J. Giordano,Arul M. Chinnaiyan,Dafydd G. Thomas,Nallasivam Palanisamy,David G. Beer,Sooryanarayana Varambally +11 more
TL;DR: The regulatory mechanisms by which purine biosynthetic pathway enzymes PPAT and PAICS, and pyruvate kinase activity is increased and exposes an existing metabolic vulnerability in lung cancer cells that can be explored for pharmacological intervention are revealed.
Journal ArticleDOI
Genetic and Histopathologic Intertumor Heterogeneity in Primary Aldosteronism
Kei Omata,Kei Omata,Yuto Yamazaki,Yasuhiro Nakamura,Yasuhiro Nakamura,Sharath Kumar Anand,Justine A. Barletta,Hironobu Sasano,William E. Rainey,Scott A. Tomlins,Anand Vaidya +10 more
TL;DR: The findings suggest that the syndrome of PA can involve heterogeneous and multiclonal functional adrenal adenomas, and complex intertumor heterogeneity in histology, steroidogenesis, and somatic mutations in multiple adrenocortical adenoma arising in a single patient with PA.
Journal ArticleDOI
Trends in acute ischemic stroke treatments and mortality in the United States from 2012 to 2018.
Sharath Kumar Anand,William J Benjamin,Arjun R. Adapa,Jiwon V Park,D. Andrew Wilkinson,Badih J Daou,James F. Burke,Aditya S Pandey +7 more
TL;DR: In this paper, the authors identified temporal trends in the usage of tissue-type plasminogen activator (tPA) and mechanical thrombectomy (MT) within the acute ischemic stroke (AIS) population from 2012 to 2018, and the relationship to mortality.