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Sharmistha Sinha
Researcher at University of California, Los Angeles
Publications - 71
Citations - 2775
Sharmistha Sinha is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Bacterial microcompartment & Chemistry. The author has an hindex of 24, co-authored 60 publications receiving 2445 citations. Previous affiliations of Sharmistha Sinha include Massachusetts Institute of Technology & United States Department of Veterans Affairs.
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Journal ArticleDOI
N-linked oligosaccharides as outfitters for glycoprotein folding, form and function
TL;DR: It is evident that glycosylation is a multifaceted post-translational modification that serves to "outfit" proteins for fold-function balance.
Journal ArticleDOI
Lysine-Specific Molecular Tweezers Are Broad-Spectrum Inhibitors of Assembly and Toxicity of Amyloid Proteins
Sharmistha Sinha,Dahabada H. J. Lopes,Zhenming Du,Eric Pang,Akila Shanmugam,Aleksey Lomakin,Peter Talbiersky,Annette Tennstaedt,Kirsten McDaniel,Reena Bakshi,Pei-Yi Kuo,Michael Ehrmann,George B. Benedek,Joseph A. Loo,Frank-Gerrit Klärner,Thomas Schrader,Chunyu Wang,Gal Bitan +17 more
TL;DR: In this article, the authors examined Lys-specific molecular tweezers and discovered a lead compound termed CLR01, which is capable of inhibiting the aggregation and toxicity of multiple amyloidogenic proteins by binding to Lys residues and disrupting hydrophobic and electrostatic interactions important for nucleation, oligomerization, and fibril elongation.
Lysine-specific molecular tweezers are broad-spectrum inhibitors of assembly and toxicity of amyloid proteins
Sharmistha Sinha,Dahabada H. J. Lopes,Zhenming Du,Eric Pang,Akila Shanmugam,Aleksey Lomakin,Peter Talbiersky,Annette Tennstaedt,Kirsten McDaniel,Reena Bakshi,Pei-Yi Kuo,Michael Ehrmann,George B. Benedek,Joseph A. Loo,Frank-Gerrit Klärner,Thomas Schrader,Chunyu Wang,Gal Bitan +17 more
TL;DR: The data suggest that molecular tweezers are unique, process-specific inhibitors of aberrant protein aggregation and toxicity, which hold promise for developing disease-modifying therapy for amyloidoses.
Journal ArticleDOI
Diverse Bacterial Microcompartment Organelles
TL;DR: The growing understanding of MCPs is providing a basis for bioengineering of protein-based containers for the production of chemicals/pharmaceuticals and for use as molecular delivery vehicles.
Journal ArticleDOI
A Novel "Molecular Tweezer" Inhibitor of α-Synuclein Neurotoxicity in Vitro and in Vivo
Shubhangi Prabhudesai,Sharmistha Sinha,Aida Attar,Aswani Kotagiri,Arthur G. Fitzmaurice,Rajeswari Lakshmanan,Magdalena I. Ivanova,Joseph A. Loo,Frank-Gerrit Klärner,Thomas Schrader,Mark Stahl,Gal Bitan,Jeff M. Bronstein,Jeff M. Bronstein +13 more
TL;DR: The data suggest that CLR01 is a promising therapeutic agent for the treatment of Parkinson’s disease and other synucleinopathies.