S
Sharon J. Peacock
Researcher at University of Cambridge
Publications - 523
Citations - 42576
Sharon J. Peacock is an academic researcher from University of Cambridge. The author has contributed to research in topics: Burkholderia pseudomallei & Melioidosis. The author has an hindex of 90, co-authored 494 publications receiving 33352 citations. Previous affiliations of Sharon J. Peacock include University of London & Health Protection Agency.
Papers
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Journal ArticleDOI
Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19): A Review.
W. Joost Wiersinga,Andrew Rhodes,Allen C. Cheng,Sharon J. Peacock,Sharon J. Peacock,Hallie C. Prescott +5 more
TL;DR: This review discusses current evidence regarding the pathophysiology, transmission, diagnosis, and management of COVID-19, the novel severe acute respiratory syndrome coronavirus 2 pandemic that has caused a worldwide sudden and substantial increase in hospitalizations for pneumonia with multiorgan disease.
Journal ArticleDOI
SARS-CoV-2 variants, spike mutations and immune escape.
William T. Harvey,Alessandro M Carabelli,Ben Jackson,Ravindra K. Gupta,E. Thomson,E. Thomson,Ewan M. Harrison,Ewan M. Harrison,Catherine Ludden,Richard Reeve,Andrew Rambaut,Sharon J. Peacock,David Robertson +12 more
TL;DR: A review of the literature on mutations of the SARS-CoV-2 spike protein, the primary antigen, focusing on their impacts on antigenicity and contextualizing them in the protein structure is presented in this article.
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Evolution of MRSA During Hospital Transmission and Intercontinental Spread
Simon R. Harris,Edward J. Feil,Matthew T. G. Holden,Michael A. Quail,Emma K. Nickerson,Emma K. Nickerson,Narisara Chantratita,Susana Gardete,Susana Gardete,Ana Tavares,Nicholas P. J. Day,Nicholas P. J. Day,Jodi A. Lindsay,Jonathan D. Edgeworth,Jonathan D. Edgeworth,Hermínia de Lencastre,Hermínia de Lencastre,Julian Parkhill,Sharon J. Peacock,Sharon J. Peacock,Stephen D. Bentley +20 more
TL;DR: A high-throughput genomics approach is used to show that isolates of methicillin-resistant Staphylococcus aureus are precisely differentiated into a global geographic structure and suggest that intercontinental transmission has occurred for nearly four decades.
Journal ArticleDOI
Complete genomes of two clinical Staphylococcus aureus strains: Evidence for the rapid evolution of virulence and drug resistance
Matthew T. G. Holden,Edward J. Feil,Jodi A. Lindsay,Sharon J. Peacock,Nicholas P. J. Day,Mark C. Enright,Timothy J. Foster,Catrin E. Moore,Laurence D. Hurst,Rebecca Atkin,Andrew Barron,Nathalie Bason,Stephen D. Bentley,Carol Chillingworth,Tracey Chillingworth,Carol Churcher,Louise Clark,Craig Corton,Ann Cronin,Jon Doggett,Linda Dowd,Theresa Feltwell,Zahra Hance,Barbara Harris,Heidi Hauser,S. Holroyd,Kay Jagels,Keith D. James,Nicola Lennard,Alexandra Line,Rebecca Mayes,Sharon Moule,Karen Mungall,Douglas Ormond,Michael A. Quail,Ester Rabbinowitsch,Kim Rutherford,Mandy Sanders,Sarah Sharp,Mark Simmonds,K. Stevens,Sally Whitehead,Bart Barrell,Brian G. Spratt,Julian Parkhill +44 more
TL;DR: The crucial role that accessory elements play in the rapid evolution of S. aureus is clearly illustrated by comparing the MSSA476 genome with that of an extremely closely related MRSA community-acquired strain; the differential distribution of large mobile elements carrying virulence and drug-resistance determinants may be responsible for the clinically important phenotypic differences in these strains.
Journal ArticleDOI
Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study.
Laura García-Álvarez,Matthew T. G. Holden,Heather Lindsay,Cerian R. Webb,Derek F. J. Brown,Martin D. Curran,Enid Walpole,Karen Brooks,Derek Pickard,Christopher Teale,Julian Parkhill,Stephen D. Bentley,Giles Edwards,E Kirsty Girvan,Angela M. Kearns,Bruno Pichon,Robert Hill,Anders Rhod Larsen,Robert Skov,Sharon J. Peacock,Duncan J. Maskell,Mark A. Holmes +21 more
TL;DR: The discovery of a strain of S aureus isolated from bulk milk that was phenotypically resistant to meticillin but tested negative for the mecA gene is reported and new diagnostic guidelines for the detection of MRSA should consider the inclusion of tests for mecALGA251.