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Shavanthi Rajatileka
Researcher at University of the West of England
Publications - 16
Citations - 1166
Shavanthi Rajatileka is an academic researcher from University of the West of England. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 9, co-authored 10 publications receiving 831 citations. Previous affiliations of Shavanthi Rajatileka include University of Bristol & Vector Group Ltd..
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Journal ArticleDOI
A mutation in the voltage-gated sodium channel gene associated with pyrethroid resistance in Latin American Aedes aegypti.
Karla Saavedra-Rodriguez,Ludmel Urdaneta-Marquez,Shavanthi Rajatileka,Shavanthi Rajatileka,M. Moulton,Adriana E. Flores,Ildefonso Fernández-Salas,Juan A. Bisset,Mario H. Rodriguez,Philip J. McCall,Philip J. McCall,Martin J. Donnelly,Hilary Ranson,Hilary Ranson,Janet Hemingway,William C. Black +15 more
TL;DR: The tools and information presented provide a means for early detection and characterization of kdr that is critical to the development of strategies for resistance management and showed a high rate of recombination even though the two codons are only separated by a ~250 bp intron.
Journal ArticleDOI
The role of the Aedes aegypti Epsilon glutathione transferases in conferring resistance to DDT and pyrethroid insecticides
Nongkran Lumjuan,Shavanthi Rajatileka,Donch Changsom,Donch Changsom,Jureeporn Wicheer,Jureeporn Wicheer,Posri Leelapat,Posri Leelapat,La aied Prapanthadara,La aied Prapanthadara,Pradya Somboon,Gareth Lycett,Gareth Lycett,Hilary Ranson,Hilary Ranson +14 more
TL;DR: Characterization of the respective recombinant enzymes revealed that both variants have comparable DDT dehydrochlorinase activity although the isoform from the resistant strain has higher affinity for the insecticide.
Journal ArticleDOI
Pyrethroid resistance in Aedes aegypti from Grand Cayman
TL;DR: The Grand Cayman population of Aedes aegypti is highly resistant to DDT and pyrethroid insecticides, but synergist studies did not implicate elevated insecticide detoxification as a major cause of resistance.
Journal ArticleDOI
SARS-CoV-2 Omicron is an immune escape variant with an altered cell entry pathway
Brian J. Willett,Joe Grove,Oscar A. MacLean,Craig Wilkie,Giuditta De Lorenzo,Wilhelm Furnon,Diego Cantoni,S. Scott,Nicola S Logan,Shirin Ashraf,M. Manali,Agnieszka M. Szemiel,Vanessa M. Cowton,Elen Vink,Chris Davis,Patawee Asamaphan,Richard J. Orton,P Holland,Vanessa Silva,David J Pascall,Kathryn Puxty,Sharif Shaaban Muhammad Shaaban,Matthew T. G. Holden,Rute Maria Pinto,Kate Templeton,Pablo R. Murcia,Arvind H. Patel,Paul Klenerman,Susanna Dunachie,Eleanor Barnes,Anthony Brown,S Adele,Barbara Kronsteiner,Sam M. Murray,P. Abraham,Alexandra Deeks,M A Ansari,Lance Turtle,Shona C Moore,James Austin,Alex G. Richter,Christopher J A Duncan,Rebecca Payne,Amy Ehrlich Ash,C. J. Koshy,Beatrix Kele,Teresa Cutino-Moguel,Derek Fairley,James McKenna,Tanya Curran,Helen Adams,Christophe Fraser,David Bonsall,Helen R. Fryer,Katrina A. Lythgoe,Laura Hayden Thomson,Tanya Golubchik,Abigail Murray,D. Singleton,Shaun M. Beckwith,A Mantzouratou,Magdalena Barrow,Sarah L. Buchan,Nicola Reynolds,Ben Warne,Joshua Maksimovic,Karla Spellman,Kathryn Mccluggage,M. John,Robert H. Beer,Safiah Afifi,Sian Natasha Morgan,Andrew L. Mack,Angela Marchbank,Anna Price,A.C. Morriss,Catherine Bresner,Christine Kitchen,I. Merrick,Joel Southgate,Martyn F Guest,Owen Bowden Jones,Robert F. Munn,Thomas R. Connor,Tom Whalley,T. Race Workman,William Oliver Fuller,Amita Patel,Bindi Patel,G. Nebbia,Jonathan D. Edgeworth,Luke B Snell,Rahul Batra,Themoula Charalampous,Angela Helen Beckett,Ekaterina Shelest,Samuel Robson,Anthony Underwood,Benjamin Taylor,Corin Yeats,David M. Aanensen,Khalil Abudahab,Mirko Menegazzo,Amelia Joseph,Gemma Clark,Hannah C. Howson-Wells,Louise Berry,Manjinder Khakh,Michelle Lister,T. Boswell,Vicki M. Fleming,Christopher W Holmes,Claire McMurray,Jessica R. Shaw,Julian W. Tang,Karlie Fallon,Minaxshi Odedra,Nicholas J. Willford,Paul W Bird,Thomas Helmer,L.A. Williams,Nicole R. Sheriff,Sharon Campbell,Veena Raviprakash,Vickie L. Blakey,Christopher I. Moore,Fei Sang,Johnny Debebe,Matthew Carlile,Matthew Loose,Nadine Holmes,Victoria Wright,M. Torok,William L Hamilton,Alessandro M Carabelli,Andrew Jermy,Beth Blane,Carol Churcher,Catherine Ludden,Dinesh Aggarwal,Elaine J. Westwick,Ellen Brigid Brooks,Georgina M. McManus,Katerina Galai,Ken R. Smith,Kim Smith,MacGregor Cox,Mireille Fragakis,Patrick Maxwell,Sarah Judges,Sharon J. Peacock,Theresa Feltwell,A. K. Kenyon,Sahar Eldirdiri,Thomas Davis,Joshua F. Taylor,NgeeKeong Tan,Alexander E. Zarebski,Bernardo Gutierrez,Jayna Raghwani,Louis du Plessis,Moritz U. G. Kraemer,Oliver G. Pybus,Sarah François,S. W. Attwood,Tetyana I. Vasylyeva,Aminu S Jahun,Ian Goodfellow,Iliana Georgana,Malte L Pinckert,Myra Hosmillo,Rhys E. Izuagbe,Yasmin Chaudhry,Felicity Ryan,Hannah Louise Lowe,Samuel Rajan Moses,Luke Bedford,James S Cargill,Warwick S. Hughes,J. Moore,Susanne Stonehouse,Divya Shah,Jack Lee,Julianne R Brown,Kathryn A. Harris,Laura Atkinson,Nathaniel Storey,Moira J. Spyer,Flavia Flaviani,Adela Alcolea-Medina,J. Sehmi,John Ramble,Natasha Ohemeng-Kumi,P. Smith,B. Bertolusso,Claire P Thomas,Gabrielle Vernet,Jessica Lynch,Nathan Moore,Nicholas Cortes,Rebecca Williams,Stephen P. Kidd,L. J. Levett,Monika Pusok,Paul Grant,Stuart Kirk,W. J. Chatterton,Li Xu-McCrae,Darren L. Smith,Gregor Young,Matthew Bashton,Katie Kitchman,Kavitha Gajee,K. Eastick,Patrick J. Lillie,Phillipa Burns,William G. Everson,Alison Cox,Alison Holmes,Frances Bolt,James R. Price,Marcus Pond,Paul Randell,Pinglawathee Madona,Siddharth Mookerjee,Erik M. Volz,Lily Geidelberg,Manon Ragonnet-Cronin,Olivia Boyd,Robert Johnson,Cassie F Pope,Adam A. Witney,Irene M. Monahan,Ken Laing,Katherine Smollett,Alan McNally,Joanne Stockton,Joshua Quick,Nicholas J. Loman,Radoslaw Poplawski,Samuel M. Nicholls,Will P. M. Rowe,Anibolina Castigador,Emily Macnaughton,Kate El Bouzidi,Malur Sudhanva,Temi Lampejo,Rocio Martinez Nunez,Cathy Breen,Graciela Sluga,Karen T. Withell,Nicholas W Machin,Ryan George,Shazaad Ahmad,David Pritchard,D. Binns,Nick Wong,Victoria L. James,Cheryl Williams,Christopher J. R. Illingworth,Christopher Jackson,Daniela De Angelis,Afrida Mukaddas,Alice Broos,Ana da Silva Filipe,Daniel Mair,David Robertson,Derek W. Wright,E. Thomson,Igor Starinskij,Ioulia Tsatsani,James Shepherd,Jenna Nichols,Joseph Hughes,Kyriaki Nomikou,Lily Tong,Sreenu B. Vattipally,William T. Harvey,Roy A. Sanderson,S. O’Brien,Steven Rushton,Jon Davis Perkins,Rachel Blacow,Rory Gunson,A. Gallagher,Elizabeth Wastnedge,Martin P McHugh,Rebecca Dewar,Seb Cotton,Lindsay Coupland,R.Suganya and Dr. Shaleesha A. Stanley,Samir Dervisevic,Lewis G. Spurgin,Louise Smith,Clive Graham,D. Padgett,Edward Barton,Garren Scott,Aidan Cross,Mariyam Mirfenderesky,E. Swindells,J Greenaway,Rebecca Denton-Smith,Robyn Turnbull,Giles Idle,Kevin Cole,Amy Louise Hollis,Andrew T. Nelson,C. McCann,Joan H Henderson,M. Crown,Wen Chyin Yew,W Stawski Stanley,Nicholas Duckworth,Phillip Clarke,Sarah Walsh,Tim J. Sloan,Kelly Bicknell,R. L. Impey,Sarah Wyllie,Scott M. Elliott,Sharon Glaysher,Declan Bradley,Nicholas Killough,Tim W. Wyatt,Andrew Bosworth,Barry Vipond,Clare Pearson,Elias Allara,E. E Robinson,Hannah M. Pymont,Husam Osman,Peter C. Muir,Richard Hopes,S. A. Hutchings,Martin D. Curran,Surendra S. Parmar,A Thornton,Angie Lackenby,Chloe Bishop,David F. Bibby,Dave Lee,Eileen Gallagher,Gavin Dabrera,Ian Harrison,Jonathan Hubb,Katherine A. Twohig,Meera Chand,Nicholas Ellaby,Nikos Manesis,R. Myers,Steven Platt,Tamyo Mbisa,Vicki Chalker,Gonzalo Yebra,Stefan Rooke,Alec Birchley,Alexander Adams,A Davies,Amy E. Gaskin,Bree Gatica-Wilcox,Caoimhe McKerr,Catherine Moore,Catryn Williams,Chris Williams,David Heyburn,Elen de Lacy,Ember Hilvers,Fatima Downing,Georgia Pugh,Hannah Jones,Hibo Asad,Jason D. Coombes,Jessica G. Hey,Jessica L. Powell,Joanne Watkins,John Evans,Laia Fina,Laura Gifford,L Gilbert,Lee H. Graham,Malorie Perry,Mari Morgan,Matthew Bull,Nicole Pacchiarini,Noel Craine,Sally Corden,Sara Kumžiene-Summerhayes,Sara Rey,Sarah Taylor,Simon Cottrell,Sophie Jones,Sue Edwards,Tara Annett,Alexander J. Trotter,Alison E. Mather,Alp Aydin,Andrew J. Page,David J. Baker,Ebenezer Foster-Nyarko,Gemma L. Kay,Justin O'Grady,Leonardo de Oliveira Martins,Lizzie Meadows,Nabil-Fareed Alikhan,Sophie J Prosolek,Steven J. Rudder,Thanh Le-Viet,Anna Casey,Liz Ratcliffe,Aditi Singh,Arun Mariappan,Chris L. Baxter,Clara Radulescu,David Simpson,Debra Redman Lavin,Fiona Rogan,Julia Miskelly,Marc Fuchs,Miao Tang,Sílvia F. Carvalho,Stephen Bridgett,Timofey Skvortsov,Zoltán Molnár,Newara Ramadan,Bridget A. Knight,Christopher R. Jones,Cressida Auckland,Helen Morcrette,Jennifer Lee Poyner,Dianne Irish-Tavares,Eric Witele,Jennifer Hart,Tabitha Mahungu,Tanzina Haque,Yann Bourgeois,Christopher Fearn,Kate Cook,Katie F. Loveson,Salman Goudarzi,Cariad Evans,David G Partridge,Katie Johnson,Mehmet Yavus,Mohammad Raza,Craig Mower,Paul Baker,Sarah Essex,Stephen Bonner,Leanne Murray,Louisa K. Watson,Steven P. Liggett,Andrew I. Lawton,Ronan A Lyons,Brendan A I Payne,G Eltringham,Jennifer Collins,Sheila Waugh,Shirelle Burton-Fanning,Yusri Taha,Christopher Jeanes,Andrea N. Gomes,Darren Murray,Maimuna Kimuli,D Dobie,Paula Ashfield,Angus I. Best,Benita Percival,Emma Moles-Garcia,F. Ashford,Jeremy Mirza,L. Crawford,Megan Mayhew,Nicola Cumley,Oliver Megram,Dan Frampton,Judith Heaney,Matthew Byott,C. Houlihan,Charlotte A Williams,Eleni Nastouli,Helen Lowe,John A. Hartley,Judith Breuer,Laurentiu Maftei,Leah Ensell,Marius Cotic,Matteo Mondani,Molly Driscoll,N. Bayzid,Rachel Williams,Sunando Sur Roy,Adhyana I K Mahanama,Buddhini Samaraweera,Eleri Wilson-Davies,Emanuela Pelosi,H.C Umpleby,Helen Wheeler,Jacqui Prieto,Kordo Saeed,Matthew Harvey,Sarah Jeremiah,Siona Silviera,Stephen Aplin,T. Sass,BS Macklin,Dorian Crudgington,Liz Sheridan,Benjamin J. Cogger,Cassandra Malone,Florence Munemo,Hannah Huckson,Jonathan Lewis,Lisa J. Easton,Manasa Mutingwende,Michelle J. Erkiert,Mohammed O. Hassan-Ibrahim,N. Chaloner,Olga Podplomyk,Paul Randell,Roberto Nicodemi,Sarah L. Lowdon,Thomas Somassa,Andrew Beggs,Andrew Hesketh,Colin P. Smith,Giselda Bucca,Christopher Ruis,Claire Cormie,Ellen E. Higginson,Jamie Young,Joana Dias,L. Kermack,Mailis Maes,Ravi Gupta,Sally Forrest,Sophia T. Girgis,Rose K Davidson,Áine O'Toole,Andrew Rambaut,Ben Jackson,Carlos Balcazar,Daniel S. Maloney,Emily Scher,J. McCrone,Katherine A. Williamson,Michael D. Gallagher,Nathan C Medd,Rachel M. Colquhoun,Thomas D. Stanton,Thomas C Williams,Verity Hill,Aaron R. Jeffries,Ben Temperton,Christine Sambles,David J. Studholme,Joanna Warwick-Dugdale,Leigh Jackson,Michelle Michelsen,R. Manley,Stephen L. Michell,Alistair C. Darby,Anita Lucaci,Charlotte Nelson,Claudia Wierzbicki,Edith E. Vamos,Hermione J. Webster,Kathryn A. Jackson,Lucille Rainbow,Margaret Lawrence Hughes,Mark Whitehead,Matthew Gemmell,Miren Iturriza-Gomara,Richard Eccles,Richard Gregory,Sam Haldenby,Steve Paterson,Adrienn Angyal,Alexander J Keeley,Benjamin Foulkes,Benjamin B Lindsey,Dennis Wang,Hailey Hornsby,Luke R. Green,Manoj Baliram Pohare,M. Gallis,Matthew Parker,M. Whiteley,Nikki Smith,P. Wolverson,Peijun Zhang,Samantha Hansford,Sharon N. Hsu,S. Louka,Thushan I de Silva,Timothy M. Freeman,Matilde Mori,Emily J. Park,Jack Hill,Jayasree Dey,Jonathan K. Ball,Joseph G. Chappell,Patrick McClure,Timothy Byaruhanga,A Fanaie,Geraldine Yaze,Rachel A. Hilson,Amy Trebes,Angie Green,David Buck,G. Macintyre-Cockett,John A. Todd,Andrew R. Bassett,Andrew Whitwham,Cordelia Langford,Diana Rajan,Dominic P. Kwiatkowski,J. Harrison,Iraad F. Bronner,Jaime M. Tovar-Corona,Jennifier Liddle,Jillian Durham,Katherine L. Bellis,Kevin Lewis,Louise Aigrain,Nicholas Redshaw,Robert L. Davies,Robin J. Moll,Shane A. McCarthy,Stefanie V Lensing,Steven Leonard,Ben Farr,C. Scott,Charlotte M. Beaver,Cristina V. Ariani,Da Weldon,David Jackson,Emma Betteridge,Gerry Tonkin-Hill,Ian Johnston,Inigo Martincorena,James K. Bonfield,Jeffrey C. Barrett,John Sillitoe,J P Keatley,Karen A. Oliver,Keith James,Lesley Shirley,Liam J. Prestwood,Luke Foulser,Marina Gourtovaia,Matthew J. Dorman,Michael A. Quail,Michael Spencer Chapman,Naomi Park,Rich Livett,Roberto Amato,Sally Kay,Scott Goodwin,Scott Thurston,Shavanthi Rajatileka,Sónia Gonçalves,Stephanie Lo,Theo Sanderson,Alasdair MacLean,Emily Goldstein,Lynne Ferguson,Rachael M. Tomb,Jana Catalan,Neil Jones,John Haughney,Massimo Palmarini,Surajit Ray +672 more
TL;DR: In this article , the authors demonstrate substantial evasion of neutralization by Omicron BA.1 and BA.2 variants in vitro using sera from individuals vaccinated with ChAdOx1, BNT162b2 and mRNA-1273.529.
Journal ArticleDOI
Molecular Mechanism of Myosin Va Recruitment to Dense Core Secretory Granules
Flora Brozzi,Frédérique Diraison,Sophie Lajus,Shavanthi Rajatileka,Thomas Philips,Romano Regazzi,Mitsunori Fukuda,Paul Verkade,Elek Molnár,Aniko Varadi +9 more
TL;DR: This study demonstrates that multiple binding partners of BR‐MyoVa regulate SG transport, and this molecular mechanism is universally used by neuronal, endocrine and neuroendocrine cells.