Shawn B. Frost

TL;DR: The results suggest that M1 injury results in axonal sprouting near the ischemic injury and the establishment of novel connections within a distant target, and support the hypothesis that, after a cortical injury, such as occurs after stroke, cortical areas distant from the injury undergo major neuroanatomical reorganization.

TL;DR: These findings have strong clinical relevance as it has recently been shown that after injury to the motor cortex, as might occur in stroke, post‐injury behavioral experience may play an adaptive role in modifying the functional organization of the remaining, intact cortical tissue.

TL;DR: It is suggested that neurophysiologic reorganization of remote cortical areas occurs in response to cortical injury and that the greater the damage to reciprocal intracortical pathways, the great the plasticity in intact areas.

TL;DR: Results support the feasibility of using a therapy approach combining peri-infarct electrical stimulation with rehabilitative training to alleviate chronic motor deficits and promote recovery from cortical ischemic injury.

TL;DR: The results suggest that after a lesion in the M1 DFL, the induction of representational plasticity in PMv, as evaluated using intracortical microstimulation, is related more to the size of the lesion than to the disruption of its intrACortical connections.