S
Shawn M. Ferguson
Researcher at Yale University
Publications - 87
Citations - 7713
Shawn M. Ferguson is an academic researcher from Yale University. The author has contributed to research in topics: Lysosome & Dynamin. The author has an hindex of 38, co-authored 81 publications receiving 6452 citations. Previous affiliations of Shawn M. Ferguson include Vanderbilt University Medical Center & Vanderbilt University.
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Journal ArticleDOI
The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis
Agnes Roczniak-Ferguson,Constance S. Petit,Florian Froehlich,Sharon Qian,Jennifer Ky,Brittany Angarola,Tobias C. Walther,Shawn M. Ferguson +7 more
TL;DR: TFEB is identified as a target of mTOR and a mechanism for matching the transcriptional regulation of genes encoding proteins of autophagosomes and lysosomes to cellular need is suggested.
Journal ArticleDOI
Dynamin, a membrane-remodelling GTPase
TL;DR: Understanding of the mechanisms by which dynamin acts, its essential roles in cell physiology and the specific function of different dynamin isoforms are improved, highlighting specific contributions of this GTPase to the physiology of different tissues.
Journal ArticleDOI
A Selective Activity-Dependent Requirement for Dynamin 1 in Synaptic Vesicle Endocytosis
Shawn M. Ferguson,Gabor Brasnjo,Mitsuko Hayashi,Markus Wölfel,Chiara Collesi,Silvia Giovedì,Andrea Raimondi,Liang Wei Gong,Pablo Ariel,Summer Paradise,Eileen T. O'Toole,Richard A. Flavell,Ottavio Cremona,Gero Miesenböck,Timothy A. Ryan,Pietro De Camilli +15 more
TL;DR: In this article, a neuron-specific guanosine triphosphatase (Dynamin 1) was found to be critically required for the fission reaction of synaptic vesicle endocytosis.
Journal ArticleDOI
Coordinated Actions of Actin and BAR Proteins Upstream of Dynamin at Endocytic Clathrin-Coated Pits
Shawn M. Ferguson,Andrea Raimondi,Summer Paradise,Hongying Shen,Kumi Mesaki,Agnes Ferguson,Olivier Destaing,Genevieve Ko,Junko Takasaki,Ottavio Cremona,Eileen O' Toole,Pietro De Camilli +11 more
TL;DR: A concerted action of actin-nucleating proteins prior to, and independent of, dynamin is demonstrated and similarities between clathrin-mediated endocytosis in yeast and higher eukaryotes are emphasized.
Journal ArticleDOI
Recruitment of Endophilin to Clathrin-Coated Pit Necks Is Required for Efficient Vesicle Uncoating after Fission
Ira Milosevic,Silvia Giovedì,Xuelin Lou,Andrea Raimondi,Chiara Collesi,Chiara Collesi,Hongying Shen,Summer Paradise,Eileen T. O'Toole,Shawn M. Ferguson,Ottavio Cremona,Pietro De Camilli +11 more
TL;DR: The data support a model in which endophilin recruitment to coated pit necks, because of its curvature-sensing properties, primes vesicle buds for subsequent uncoating after membrane fission, without being critically required for the fission reaction itself.