Sheena McGowan

TL;DR: Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes, central in controlling many important proteolytic cascades, including the mammalian coagulation pathways.

TL;DR: The results reveal the immense potential for translating the dispersed expertise in biological assays involving human pathogens into drug discovery starting points, by providing open access to new families of molecules, and emphasize how a small additional investment made to help acquire and distribute compounds, and sharing the data, can catalyze drug discovery for dozens of different indications.

TL;DR: The Medicines for Malaria Venture Malaria Box as mentioned in this paper is a collection of over 400 compounds representing families of structures identified in phenotypic screens of pharmaceutical and academic libraries against the Plasmodium falciparum malaria parasite.

TL;DR: In this article, the neutral aminopeptidases of the malaria parasite were characterized using X-ray crystal structure and substrate specificity, which set the groundwork for the development of antimalarial therapeutics.

TL;DR: Recent biochemical, structural and functional studies provide the substrate specificity and mechanistic binding data needed to guide the development of more potent anti-malarial drugs, and form the rationale for choosing PfM1AAP and PfM17LAP as targets for anti- malarial development.