S
Sheldon R. Morris
Researcher at University of California, San Diego
Publications - 122
Citations - 3316
Sheldon R. Morris is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Men who have sex with men & Pre-exposure prophylaxis. The author has an hindex of 30, co-authored 105 publications receiving 2520 citations. Previous affiliations of Sheldon R. Morris include California Health and Human Services Agency & Washington University in St. Louis.
Papers
More filters
Journal ArticleDOI
ADAR1 Activation Drives Leukemia Stem Cell Self-Renewal by Impairing Let-7 Biogenesis
Maria A. Zipeto,Angela C. Court,Anil Sadarangani,Nathaniel Delos Santos,Larisa Balaian,Hye Jung E. Chun,Gabriel Pineda,Sheldon R. Morris,Cayla Mason,Ifat Geron,Christian L. Barrett,Daniel Goff,Russell Wall,Maurizio Pellecchia,Mark D. Minden,Kelly A. Frazer,Marco A. Marra,Leslie Crews,Qingfei Jiang,Catriona Jamieson +19 more
TL;DR: Combined RNA sequencing, qRT-PCR, CLIP-ADAR1, and pri-let-7 mutagenesis data suggest that ADAR1 promotes LSC generation via let-7 pri-microRNA editing and LIN28B upregulation and a small-molecule tool compound antagonizes ADar1's effect on LSC self-renewal in stromal co-cultures and restores let- 7 biogenesis.
Journal ArticleDOI
A Pan-BCL2 Inhibitor Renders Bone-Marrow-Resident Human Leukemia Stem Cells Sensitive to Tyrosine Kinase Inhibition
Daniel Goff,Angela Court Recart,Anil Sadarangani,Hye Jung E. Chun,Christian L. Barrett,Maryla Krajewska,Heather Leu,Janine M. Low-Marchelli,Wenxue Ma,Alice Y. Shih,Jun Wei,Dayong Zhai,Ifat Geron,Minya Pu,Lei Bao,Ryan Chuang,Larisa Balaian,Jason Gotlib,Mark D. Minden,Giovanni Martinelli,Jessica M. Rusert,Kim Hien T. Dao,Kamran Shazand,Peggy Wentworth,Kristen M. Smith,Christina Jamieson,Sheldon R. Morris,Karen Messer,Lawrence S.B. Goldstein,Thomas J. Hudson,Marco A. Marra,Kelly A. Frazer,Maurizio Pellecchia,John C. Reed,Catriona Jamieson +34 more
TL;DR: These studies show that the alternative splicing of multiple prosurvival BCL2 family genes promotes malignant transformation of myeloid progenitors into BC LSCS that are quiescent in the marrow niche and that contribute to therapeutic resistance, and suggest that the combinatorial inhibition of prosurVival Bcl2 family proteins and BCR-ABL may eliminate dormant LSCs and obviate resistance.
Journal ArticleDOI
Randomized Trial of Lactin-V to Prevent Recurrence of Bacterial Vaginosis
Craig R. Cohen,Michael R. Wierzbicki,Audrey L. French,Sheldon R. Morris,Sara J. Newmann,Hilary Reno,Lauri Green,Steve Miller,Jonathan D. Powell,Thomas P. Parks,Anke Hemmerling +10 more
TL;DR: The use of Lactin-V after treatment with vaginal metronidazole resulted in a significantly lower incidence of recurrence of bacterial vaginosis than placebo at 12 weeks.
Journal ArticleDOI
ADAR1 promotes malignant progenitor reprogramming in chronic myeloid leukemia
Qingfei Jiang,Leslie Crews,Christian L. Barrett,Hye Jung E. Chun,Angela C. Court,Jane Isquith,Jane Isquith,Maria A. Zipeto,Maria A. Zipeto,Daniel Goff,Mark D. Minden,Anil Sadarangani,Jessica M. Rusert,Kim Hien T. Dao,Sheldon R. Morris,Lawrence S.B. Goldstein,Marco A. Marra,Kelly A. Frazer,Catriona Jamieson +18 more
TL;DR: In this paper, whole-transcriptome sequencing of normal, chronic phase, and serially transplantable blast crisis chronic myeloid leukemia (CML) progenitors revealed increased IFNγ pathway gene expression in concert with BCR-ABL amplification, enhanced expression of the IFN-responsive ADAR1 p150 isoform, and a propensity for increased adenosine-to-inosine RNA editing during CML progression.
Journal ArticleDOI
Prevalence and incidence of pharyngeal gonorrhea in a longitudinal sample of men who have sex with men: the EXPLORE study.
Sheldon R. Morris,Jeffrey D. Klausner,Susan Buchbinder,Sarah Wheeler,Beryl A. Koblin,Thomas J. Coates,Margaret A. Chesney,Grant Colfax +7 more
TL;DR: The pharynx is a common, asymptomatic reservoir for gonorrhea in sexually active MSM, and was positively associated with younger age and the number of insertive oral sex partners in the past 3 months.