Mandibular fracture healing is a complex process involving nerves and growth factors. Nerve growth factor (NGF) not only facilitates the maintenance of sympathetic neurite growth but also stimulates other growth factors that can promote the essential osteogenesis and angiogenesis for fracture healing. Therefore, it is necessary to analyze the combined effects of NGF, bone morphogenic protein-9 (BMP-9), and vascular endothelial growth factor (VEGF) to accelerate the healing of mandible fractures. The models of mandible fracture with local nerve injury established in 48 rabbits were randomly divided into nerve growth factor group (NGF group), gelatin sponge group (GS group), blank group, and intact group. The recovery of nerve reflex was assessed by observing the number of rabbits with lower lip responses to acupuncture. The fracture healing was observed with visual and CBCT, and then callus tissues from the mandibular fracture area were collected for hematoxylin and eosin (HE) staining observation, and the expression of BMP-9 and VEGF in callus at different stages was detected by quantitative real-time PCR (qRT-PCR). Needling reaction in the lower lip showed the number of animals with nerve reflex recovery was significantly higher in the NGF group than that in the GS and blank groups at the 2nd and 4th weeks after the operation. The combined results of macroscopic observation, CBCT examination, and histological analysis showed that a large number of osteoblasts and some vascular endothelial cells were found around the trabecular bone in the NGF group and the amount of callus formation and reconstruction was better than that in the GS group at the 2nd week after the operation. The qRT-PCR results indicated that the expression levels of BMP-9 and VEGF in the four groups reached the highest values at the 2nd week, while the expression levels of both in the NGF group were significantly higher than that in the GS group. The exogenous NGF could accelerate the healing of mandible fractures. This work will provide a new foundation and theoretical basis for clarifying the mechanism of fracture healing, thereby promoting fracture healing and reducing the disability rate of patients.

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Effects of exogenous nerve growth factor on the expression of BMP-9 and VEGF in the healing of rabbit mandible fracture with local nerve injury.

Review of immunological plasma markers for longitudinal analysis of inflammation and infection in rat models

The invention relates to the field of medical apparatus and instruments, and particularly relates to an ankle joint exercising device for an orthopedics department. The device comprises a base, the left side and the right side of the base are symmetrically provided with two groups of support plates, the upper ends of the support plates are provided with arc slide grooves, slide rods are slidinglyconnected in the arc sliding grooves, a locking rotary knob is in threaded connection with the outside end of each slide rod, the upper end of a guard plate is fixedly connected with the inside ends of the two symmetrically arranged slide rods, the support plates are rotatably connected with the outside ends of support rotation shafts, brackets are fixedly connected with the inside ends of the support rotation shafts, a pedal plate is fixedly connected with the bottom ends of the brackets, a velcro tape is arranged on the pedal plate, the output end of a servo motor is fixedly connected with the support rotation shaft on the right end, a motor bracket is fixedly connected onto the servo motor, the motor bracket is fixedly connected to the outside end of the support plate on the right side,and a controller is also fixedly mounted on the upper end of the support plate on the right side. The invention provides the exercising device enabling patients to do back stretch movement of the ankle joint and accelerating recovery.

Ankle joint exercising device for orthopedics department

Discussion on bone healing rate and expression of cytokines and growth factors in rat models with simple fracture and brain injury

The invention discloses an ankle joint rehabilitation device and a training method thereof. The ankle joint rehabilitation device comprises a controller, a base, a lower limb supporting mechanism anda power driving mechanism. The lower limb supporting mechanism comprises a first guide rod, a second guide rod, a first supporting plate and a second supporting plate. One end of the second supportingplate is hinged to the first guide rod and the second guide rod. An elastic connecting mechanism at the other end of the second supporting plate is connected with the first guide rod and the second guide rod. The second supporting plate is provided with an electromagnetism generating device. The base is provided with a permanent magnet. A gap exists between the permanent magnet and the second supporting plate. The electromagnetism generating device and the permanent magnet are oppositely arranged, so a foot of a patient can passively move up and down and can also actively move down under theeffect of preset repelling force, and then the technical aim of active training and passive training is realized; meanwhile, due to the flexible characteristic of the repelling force and attracting force generated by electromagnetism, the problem that the foot of the patient is prone to injuries due to the mechanical drive is avoided.

Ankle joint rehabilitation device and training method thereof

The invention discloses a rheumatoid arthritis nursing device and a nursing method thereof. The device comprises a casing with a hollow structure inside and a lower limb supporting mechanism and a heating nursing mechanism which are disposed on the casing. The lower limb supporting mechanism comprises a driving portion, a moving portion and a supporting portion connected in sequence. The supporting portion comprises a left leg supporting assembly and a right leg supporting assembly of the same structure, and the left leg supporting assembly and the right leg supporting assembly are both connected to a telescopic mechanism. The moving portion and the telescopic mechanism which are both connected to the supporting portion are disposed at the same time, so that the moving track of a supporting block in the supporting portion is the arc track, and the problem in the prior art that the legs cannot be effectively supported by the support block due to the fact that the support block can onlymove vertically is solved. The problems of high labor intensity of medical staff and poor comfort of the patient caused by the fact that a patient needs to be moved again to form the effective supportfor the legs of the patient and the support block is solved.

Rheumatoid arthritis nursing device and nursing method thereof

The invention relates to the field of medical auxiliary equipment, in particular to a lower limb joint rehabilitation device. A foot massage mechanism in a massage mechanism comprises a driving gear driven by a driving motor and a first gear meshed with the driving gear. A roller with a protrusion is fixed on a roller shaft of the first gear. A leg massage mechanism in the massage mechanism includes a connecting rod, a rocker and a second gear engaged with the first gear, the first gear and the second gear are fixedly provided with a first rotating column and a second rotating column, the inner side of the second gear is also fixedly provided with a third rotating column, a fourth rotating column is fixedly arranged on the pedal, the two ends of the connecting rod are respectively rotatably matched with the first rotating column and the second rotating column, the two ends of the rocker are respectively rotatably matched with the third rotating column and the fourth rotating column, and the rocker is fixedly provided with a support bar, and the support bar is fixedly provided with a massage head. The invention can simultaneously perform lower limb joint exercise and lower limb massage for a patient, and solves the problem of inconvenient lower limb massage treatment for a patient in the prior art.

Lower limb joint rehabilitation device

The invention relates to the field of neck traction devices, in particular to a cervical rehabilitation training device. The device comprises a U-shaped neck support body used for supporting the jaw,a plurality of overlapping C-shaped stretching airbags are arranged outside an opening of the neck support body, the stretching airbags are communicated through hoses, concave portions of the stretching airbags are provided with a soft isolation net, meshes of the isolation net are formed in an array, each mesh of the isolation net is internally provided with an elastic airbag, the elastic airbagsare communicated in sequence through conduits in the longitudinal direction, any end, connected to the elastic airbags, of the conduits is hinged to a pressure door capable of being turned on upward,the tops of the elastic airbags in each line are communicated with the stretching airbags through transition pipes, and the bottoms of the elastic airbags in each line are connected with inflation pipes which can be inflated synchronously. The cervical rehabilitation training device has the advantages that the firstly performed massage makes the blood flow of the cervical vertebrae faster, that is, the cervical vertebrae is gently stretched after being pre-activated, so that a patient can adapt to training better, and the cervical vertebrae is gently massaged and stretched to avoid secondaryinjury.

Shen Yang

Papers

Discussion on bone healing rate and expression of cytokines and growth factors in rat models with simple fracture and brain injury

Ankle joint rehabilitation device and training method thereof

Rheumatoid arthritis nursing device and nursing method thereof

Lower limb joint rehabilitation device

Cervical rehabilitation training device