S
Shengrong Sun
Researcher at Wuhan University
Publications - 130
Citations - 2414
Shengrong Sun is an academic researcher from Wuhan University. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 23, co-authored 99 publications receiving 1480 citations.
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Breast cancer subtypes predict the preferential site of distant metastases: a SEER based study
TL;DR: The pathological subtypes of breast cancer are clearly different in metastatic behavior with regard to the sites of distant metastasis, emphasizing that this knowledge may help to determine the appropriate strategy for follow-up and guide personalized medicine.
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Cancer-associated adipocytes: key players in breast cancer progression.
TL;DR: A better understanding of cancer-associated adipocytes and the key molecular events in the adipocyte-cancer cell crosstalk will provide insights into tumor biology and permit the optimization of therapeutic strategies.
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Exosomes from the tumour-adipocyte interplay stimulate beige/brown differentiation and reprogram metabolism in stromal adipocytes to promote tumour progression
Qi Wu,Juanjuan Li,Zhiyu Li,Si Sun,Shan Zhu,Lijun Wang,Juan Wu,Jingping Yuan,Yimin Zhang,Shengrong Sun,Changhua Wang +10 more
TL;DR: These results demonstrate that by inducing beige/brown differentiation and enhancing catabolism in recipient adipocytes, exosomal mi RNA-144 and miRNA-126 from the tumour-adipocyte interaction reprogram systemic energy metabolism to facilitate tumour progression.
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Tumour-originated exosomal miR-155 triggers cancer-associated cachexia to promote tumour progression.
Qi Wu,Si Sun,Zhiyu Li,Qian Yang,Bei Li,Shan Zhu,Lijun Wang,Juan Wu,Jingping Yuan,Changhua Yang,Juanjuan Li,Shengrong Sun +11 more
TL;DR: It is demonstrated that breast cancer-derived exosomes alter adipocytes and muscle cells in terms of increased catabolism characterized by the release of metabolites to facilitate tumour progression.
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Role of CCL5 in invasion, proliferation and proportion of CD44+/CD24- phenotype of MCF-7 cells and correlation of CCL5 and CCR5 expression with breast cancer progression.
TL;DR: CCL5 increased the proportion of CD44+/CD24- subpopulation and induced invasion and proliferation of MCF-7 cells, and expression of CCL5 and CCR5 in breast cancer tissue was positively correlated with breast cancer progression.