Shengtao Xu

TL;DR: It is revealed that modification of NPs is a versatile approach to explore their mode of actions, which may lead to the discovery of novel drugs.

TL;DR: Nine major targets associated with AD are highlighted and eleven multi-target design strategies classified by the involvement of AChE and related promising compounds for improved therapy of AD in recent years are described based on the nine major targets.

TL;DR: This review will classify the CBSIs into classical CBSIs and nonclassical CBSIs according to their spatial conformations and binding modes with tubulin, and highlight the privileged structures from these CBSIs in the development of tubulin inhibitors targeting the colchicine binding site.

TL;DR: The most potent compound, 13p, was 200-fold more efficacious than oridonin in MCF-7 cancer cells and induced apoptosis and cell cycle arrest at the G2/M phase, suggesting that the mitochondrial pathway was involved in the 13p-mediated apoptosis.

TL;DR: Compound 24d bound to the colchicine site of tubulin, arrested the cell cycle at the G2/M phase, induced apoptosis, depolarized mitochondria, and induced reactive oxidative stress generation in K562 cells, suggesting that 24d deserves to be further investigated as a potent and safe antitumor agent for cancer therapy.