Author
Shenguo Wang
Bio: Shenguo Wang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: PLGA & Polycaprolactone. The author has an hindex of 27, co-authored 38 publications receiving 2171 citations.
Topics: PLGA, Polycaprolactone, Apatite, Simulated body fluid, Copolymer
Papers
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TL;DR: In this paper, a new process of low-temperature deposition manufacturing (LDM) based on the layer-by-layer manufacturing method of solid freeform fabrication is proposed to fabricate poly( l -lactic acid)/(tricalcium phosphate) composite scaffolds for bone tissue engineering.
282 citations
TL;DR: The result using mouse NIH 3T3 fibroblasts as model cells to evaluate cell affinity in vitro showed the cationized gelatin-anchored PLGA (OCG-PLGA) was more favorable for cell attachment and growth than oxygen plasma treated PLGA
155 citations
TL;DR: Degradable ABA block copolymers were synthesized by the bulk copolymerization of PCL pre-polymers and l -lactide with stannous octanoate as the catalyst at 120°C for 120 h as discussed by the authors.
147 citations
TL;DR: In vitro cell culture results show that after the scaffolds have been improved by the ammonia plasma treatment and then collagen anchorage method, the human transparent cartilage cells H144, could be seeded deeply into the microtubules orientation-structured scaffolds and grew well there.
145 citations
TL;DR: In this article, the fabrication technology of Multi-nozzle Deposition Manufacturing (MDM) was proposed to fabricate porous tissue engineering scaffolds, which is based on the layer-by-layer manufacturing principle of Solid Freeform Fabrication (SFF).
123 citations
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TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
3,505 citations
TL;DR: The integration of scaffold computational design and free-form fabrication techniques presented here could prove highly useful for the construction of scaffolds that have anatomy specific exterior architecture derived from patient CT or MRI data and an interior porous architecturederived from computational design optimization.
1,399 citations
TL;DR: This feature article looks afresh at nano-HAp particles, highlighting the importance of size, crystal morphology control, and composites with other inorganic particles for biomedical material development.
1,215 citations
TL;DR: The analysis of the state of the art in the field reveals the presence of current innovative techniques for scaffolds and material manufacturing that are currently opening the way to prepare biomimetic PLGA substrates able to modulate cell interaction for improved substitution, restoration, or enhancement of bone tissue function.
Abstract: Poly(lactic-co-glycolic) acid (PLGA) has attracted considerable interest as a base material for biomedical applications due to its: (i) biocompatibility; (ii) tailored biodegradation rate (depending on the molecular weight and copolymer ratio); (iii) approval for clinical use in humans by the U.S. Food and Drug Administration (FDA); (iv) potential to modify surface properties to provide better interaction with biological materials; and (v) suitability for export to countries and cultures where implantation of animal-derived products is unpopular. This paper critically reviews the scientific challenge of manufacturing PLGA-based materials with suitable properties and shapes for specific biomedical applications, with special emphasis on bone tissue engineering. The analysis of the state of the art in the field reveals the presence of current innovative techniques for scaffolds and material manufacturing that are currently opening the way to prepare biomimetic PLGA substrates able to modulate cell interaction for improved substitution, restoration, or enhancement of bone tissue function.
1,116 citations
TL;DR: In this paper, 3D micro-AM processes have been classified into three main groups, including scalable micro-am systems, 3D direct writing, and hybrid processes, and the key processes are reviewed comprehensively.
Abstract: New microproducts need the utilization of a diversity of materials and have complicated three-dimensional (3D) microstructures with high aspect ratios. To date, many micromanufacturing processes have been developed but specific class of such processes are applicable for fabrication of functional and true 3D microcomponents/assemblies. The aptitude to process a broad range of materials and the ability to fabricate functional and geometrically complicated 3D microstructures provides the additive manufacturing (AM) processes some profits over traditional methods, such as lithography-based or micromachining approaches investigated widely in the past. In this paper, 3D micro-AM processes have been classified into three main groups, including scalable micro-AM systems, 3D direct writing, and hybrid processes, and the key processes have been reviewed comprehensively. Principle and recent progress of each 3D micro-AM process has been described, and the advantages and disadvantages of each process have been presented.
1,068 citations