Shide Shen

TL;DR: An N-heterocyclic carbene (NHC)-catalyzed formal [4 + 2] synthesis of dihydrocoumarins was realized from saturated carboxylic acids and o-quinone methides via an in situ activation strategy and results in excellent diastereoselectivity and enantioselectivities and good yields.

TL;DR: A straightforward N-heterocyclic carbene (NHC)/LiCl-mediated synthesis of dihydropyranones from α,β-unsaturated carboxylic acids and 1,3-dicarbonyl compounds was realized through the in situ activation strategy.

TL;DR: An asymmetric assembly of δ-lactams was realized via the NHC-catalyzed formal [4 + 2] annulation of acylhydrazones and 2-bromo-2-enals bearing γ-H to achieve high enantioselectivity, good yields, mild reaction conditions and potential biological significance of the final products.

TL;DR: An NHC-triggered, transition-metal-free strategy for the efficient synthesis of 2,3-disubstituted benzofuran derivatives in moderate to excellent yields from aryl or alkyl aldehydes and o-quinone methides has been developed.

TL;DR: A series of novel fused tetracyclic benzo[4,5]imidazo[1,2-a]thiopyrano[3,4-d]pyrimidin-4(3H)-one derivatives were synthesized via the reaction of aryl aldehyde, 2H-THiopyran-3,5(4H,6H)-dione, and 1H-benzo[d]IMIDazol-2-amine in glacial acetic acid.