S
Shigeo Ohno
Researcher at Yokohama City University
Publications - 310
Citations - 29245
Shigeo Ohno is an academic researcher from Yokohama City University. The author has contributed to research in topics: Protein kinase C & Cell polarity. The author has an hindex of 91, co-authored 303 publications receiving 28104 citations. Previous affiliations of Shigeo Ohno include Boston University & Indiana University.
Papers
More filters
Journal ArticleDOI
The PAR-aPKC system: lessons in polarity.
Atsushi Suzuki,Shigeo Ohno +1 more
TL;DR: Accumulating evidence has revealed that mechanisms by which the asymmetrically localized components of the PAR-aPKC system are linked with other cellular machinery for developing polarity are divergent depending on the cell type.
Journal ArticleDOI
Protein Kinase C δ Activates the MEK-ERK Pathway in a Manner Independent of Ras and Dependent on Raf
TL;DR: Results demonstrate that activation of PKCδ is sufficient for the activation of MEK and ERK and that the pathway operates in a manner dependent on c-Raf and independent of Ras.
Journal ArticleDOI
Binding of a novel SMG-1–Upf1–eRF1–eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay
Isao Kashima,Akio Yamashita,Natsuko Izumi,Naoyuki Kataoka,Ryo Morishita,Shin-ichi Hoshino,Mutsuhito Ohno,Gideon Dreyfuss,Shigeo Ohno +8 more
TL;DR: The SMG-1-mediated phosphorylation of Upf1 occurs on the association of SURF with EJC, which provides the link between the EJC and recognition of PTCs and triggers NMD.
Journal ArticleDOI
An Atypical PKC Directly Associates and Colocalizes at the Epithelial Tight Junction with ASIP, a Mammalian Homologue of Caenorhabditis elegans Polarity Protein PAR-3
Yasushi Izumi,Tomonori Hirose,Yoko Tamai,Syu-ichi Hirai,Yoji Nagashima,Toyoshi Fujimoto,Yo Tabuse,Kenneth J. Kemphues,Shigeo Ohno +8 more
TL;DR: A role for a protein complex containing ASIP and aPKC in the establishment and/or maintenance of epithelial cell polarity is suggested and its asymmetric distribution in polarized cells from worm embryo to mammalian-differentiated cells may mean that the complex functions generally in the organization of cellular asymmetry.
Journal ArticleDOI
A metalloprotease-disintegrin, MDC9/meltrin-gamma/ADAM9 and PKCdelta are involved in TPA-induced ectodomain shedding of membrane-anchored heparin-binding EGF-like growth factor.
Yasushi Izumi,Michinari Hirata,Hidetoshi Hasuwa,Ryo Iwamoto,Ryo Iwamoto,Toshiyuki Umata,Kenji Miyado,Yoko Tamai,Tomohiro Kurisaki,Atsuko Sehara-Fujisawa,Shigeo Ohno,Eisuke Mekada,Eisuke Mekada +12 more
TL;DR: It is suggested that MDC9 and PKCδ are involved in the stimulus‐coupled shedding of the proHB‐EGF ectodomain.