S
Shijun Hu
Researcher at Soochow University (Suzhou)
Publications - 94
Citations - 8060
Shijun Hu is an academic researcher from Soochow University (Suzhou). The author has contributed to research in topics: Induced pluripotent stem cell & Stem cell. The author has an hindex of 38, co-authored 89 publications receiving 7110 citations. Previous affiliations of Shijun Hu include Cardiovascular Institute of the South & Stanford University.
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Journal ArticleDOI
Global Epigenomic Reconfiguration During Mammalian Brain Development
Ryan Lister,Ryan Lister,Eran A. Mukamel,Joseph R. Nery,Mark A. Urich,Clare A. Puddifoot,Nicholas D. Johnson,Jacinta Lucero,Yun Huang,Andrew J. Dwork,Matthew D. Schultz,Matthew D. Schultz,Miao Yu,Julian Tonti-Filippini,Holger Heyn,Shijun Hu,Joseph C. Wu,Anjana Rao,Manel Esteller,Chuan He,Fatemeh Haghighi,Terrence J. Sejnowski,Terrence J. Sejnowski,M. Margarita Behrens,Joseph R. Ecker +24 more
TL;DR: The results extend the knowledge of the unique role of DNA methylation in brain development and function, and offer a new framework for testing the role of the epigenome in healthy function and in pathological disruptions of neural circuits.
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Patient-Specific Induced Pluripotent Stem Cells as a Model for Familial Dilated Cardiomyopathy
Ning Sun,Masayuki Yazawa,Jianwei Liu,Leng Han,Veronica Sanchez-Freire,Oscar J. Abilez,Enrique G. Navarrete,Shijun Hu,Li Wang,Andrew S. Lee,Aleksandra Pavlovic,Shin Lin,Rui Chen,Roger J. Hajjar,Michael Snyder,Ricardo E. Dolmetsch,Manish J. Butte,Euan A. Ashley,Michael T. Longaker,Robert C. Robbins,Joseph C. Wu +20 more
TL;DR: Human induced pluripotent stem cells generated from patients with familial dilated cardiomyopathy model cardiovascular disease could provide an important platform to investigate the specific disease mechanisms of DCM as well as other inherited cardiovascular disorders and for screening new drugs for cardiovascular disease.
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Abnormal Calcium Handling Properties Underlie Familial Hypertrophic Cardiomyopathy Pathology in Patient-Specific Induced Pluripotent Stem Cells
Feng Lan,Andrew S. Lee,Ping Liang,Veronica Sanchez-Freire,Patricia K. Nguyen,Li Wang,Leng Han,Michelle Yen,Yongming Wang,Ning Sun,Oscar J. Abilez,Shijun Hu,Antje D. Ebert,Enrique G. Navarrete,Chelsey S. Simmons,Matthew T. Wheeler,Beth L. Pruitt,Richard S. Lewis,Yoshinori Yamaguchi,Euan A. Ashley,Donald M. Bers,Robert C. Robbins,Michael T. Longaker,Joseph C. Wu +23 more
TL;DR: Patients generating patient-specific induced pluripotent stem cell cardiomyocytes from a ten-member family cohort carrying a hereditary HCM missense mutation (Arg663His) in the MYH7 gene are generated to help elucidate the mechanisms underlying HCM development and identify novel therapies for the disease.
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Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells.
Ning Sun,Nicholas J. Panetta,Deepak M. Gupta,Kitchener D. Wilson,Andrew S. Lee,Fangjun Jia,Shijun Hu,Athena M. Cherry,Robert C. Robbins,Michael T. Longaker,Joseph C. Wu +10 more
TL;DR: It is shown here that induced pluripotent stem cells can be generated from adult human adipose stem cells (hASCs) freshly isolated from patients, and can be readily derived from adult hASCs in a feeder-free condition, thereby eliminating potential variability caused by using feeder cells.
Journal ArticleDOI
MicroRNA-210 as a Novel Therapy for Treatment of Ischemic Heart Disease
Shijun Hu,Mei Huang,Zongjin Li,Fangjun Jia,Zhumur Ghosh,Maarten A. Lijkwan,Pasquale Fasanaro,Ning Sun,Xi Wang,Fabio Martelli,Robert C. Robbins,Joseph C. Wu +11 more
TL;DR: MicroRNA-210 can improve angiogenesis, inhibit apoptosis, and improve cardiac function in a murine model of myocardial infarction and represents a potential novel therapeutic approach for treatment of ischemic heart disease.