S
Shin-Ichi Hayashi
Researcher at Tottori University
Publications - 78
Citations - 5783
Shin-Ichi Hayashi is an academic researcher from Tottori University. The author has contributed to research in topics: Haematopoiesis & Stromal cell. The author has an hindex of 35, co-authored 77 publications receiving 5590 citations. Previous affiliations of Shin-Ichi Hayashi include Niigata University & Kyoto University.
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Journal ArticleDOI
The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene
Hisahiro Yoshida,Shin-Ichi Hayashi,Takahiro Kunisada,Minetaro Ogawa,Satomi Nishikawa,Hitoshi Okamura,Tetsuo Sudo,Leonard D. Shultz,Shin Ichi Nishikawa +8 more
TL;DR: It is shown that op/op fibroblasts are defective in production of functional macrophage colony-stimulating factor (M-CSF), although its messenger RNA (Csfm mRNA) is present at normal levels, and it is concluded that the pathological changes in this mutant result from the absence of M- CSF.
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Cells and Molecules that Regulate B Lymphopoiesis in Bone Marrow
TL;DR: This review focuses on cells of the humoral immune system and those steps involved in their formation that can be observed and manipulated in culture and the probable source of such regulatory substances is becoming clearer.
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Transgene expression of steel factor in the basal layer of epidermis promotes survival, proliferation, differentiation and migration of melanocyte precursors
Takahiro Kunisada,Hisahiro Yoshida,Hidetoshi Yamazaki,Akitomo Miyamoto,Hiroaki Hemmi,Emi K. Nishimura,Leonard D. Shultz,Shin-Ichi Nishikawa,Shin-Ichi Hayashi +8 more
TL;DR: Data is presented suggesting that SLF does not simply support survival and proliferation of melanocytes but also promotes differentiation of these cells, and unexpected melanocyte stem cells independent of the c-Kit signal were maintained in the skin of the SLF transgenic mice.
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Murine Cutaneous Mastocytosis and Epidermal Melanocytosis Induced by Keratinocyte Expression of Transgenic Stem Cell Factor
Takahiro Kunisada,Shu-Zhuang Lu,Hisahiro Yoshida,Satomi Nishikawa,Shin-Ichi Nishikawa,Masako Mizoguchi,Shin-Ichi Hayashi,Lynda Tyrrell,David A. Williams,Xiaomei Wang,B. Jack Longley +10 more
TL;DR: It is concluded that a phenotype matching that of human mastocytosis can be produced in mice by keratinocyte overproduction of soluble SCF, suggesting a potential cause of this disease.
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Suppression of macrophage functions impairs skeletal muscle regeneration with severe fibrosis
Masashi Segawa,So-ichiro Fukada,Yukiko Yamamoto,Hiroshi Yahagi,Masanori Kanematsu,Masaki Sato,Takahito Ito,Akiyoshi Uezumi,Shin-Ichi Hayashi,Yuko Miyagoe-Suzuki,Shin'ichi Takeda,Kazutake Tsujikawa,Hiroshi Yamamoto +12 more
TL;DR: The results indicate that macrophages directly affect satellite cell proliferation and that a macrophage deficiency severely impairs skeletal muscle regeneration and causes fibrosis.