S
Shin'ichi Yoshihara
Researcher at International University, Cambodia
Publications - 47
Citations - 2226
Shin'ichi Yoshihara is an academic researcher from International University, Cambodia. The author has contributed to research in topics: Aldehyde oxidase & Microsome. The author has an hindex of 21, co-authored 47 publications receiving 2078 citations. Previous affiliations of Shin'ichi Yoshihara include Kyushu University & Hiroshima University.
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Journal ArticleDOI
Comparative study of the endocrine-disrupting activity of bisphenol A and 19 related compounds.
Shigeyuki Kitamura,Tomoharu Suzuki,Seigo Sanoh,Ryuki Kohta,Norimasa Jinno,Kazumi Sugihara,Shin'ichi Yoshihara,Nariaki Fujimoto,Hiromitsu Watanabe,Shigeru Ohta +9 more
TL;DR: The results suggest that the 4-hydroxyl group of the A- phenyl ring and the B-phenyl ring of BPA derivatives are required for these hormonal activities, and substituents at the 3,5-positions of the phenyl rings and the bridging alkyl moiety markedly influence the activities.
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Possible correlation between induction modes of hepatic enzymes by PCBs and their toxicity in rats.
TL;DR: The results suggest that the toxic potency of PCBs is related to their MC-type inducing ability, but the toxic characteristics are different from those of MC itself.
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Potent Estrogenic Metabolites of Bisphenol A and Bisphenol B Formed by Rat Liver S9 Fraction: Their Structures and Estrogenic Potency
Shin'ichi Yoshihara,Tohru Mizutare,Misako Makishima,Noriko Suzuki,Nariaki Fujimoto,Kazuo Igarashi,Shigeru Ohta +6 more
TL;DR: The results strongly suggest that the active metabolite of either BPA or BPB might be formed by recombination of a radical fragment, a one-electron oxidation product of carbon-phenyl bond cleavage.
Journal Article
New aspects of cadmium as endocrine disruptor.
TL;DR: Evidence thus far presented concerning the effects of Cd on the endocrine system is discussed and it is shown that Cd has potent estrogen- and androgens-like activities in vivo and in vitro, by directly binding to estrogen and androgen receptors.
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Metabolic activation of bisphenol A by rat liver S9 fraction.
TL;DR: The present results clearly indicate that BPA is metabolically activated in terms of estrogenicity under the conditions existing only with combined rat liver microsomes and cytosol.