S
Shirley M. Taylor
Researcher at Stellenbosch University
Publications - 3
Citations - 2960
Shirley M. Taylor is an academic researcher from Stellenbosch University. The author has contributed to research in topics: Cellular differentiation & DNA. The author has an hindex of 3, co-authored 3 publications receiving 2873 citations.
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Journal ArticleDOI
Cellular differentiation, cytidine analogs and DNA methylation
Peter A. Jones,Shirley M. Taylor +1 more
TL;DR: Results provide experimental evidence for a role for DNA modification in differentiation, and suggest that cytidine analogs containing an altered 5 position perturb previously established methylation patterns to yield new cellular phenotypes.
Journal ArticleDOI
Multiple new phenotypes induced in 10T1/2 and 3T3 cells treated with 5-azacytidine.
Shirley M. Taylor,Peter A. Jones +1 more
TL;DR: Three new mesenchymal phenotypes were expressed in cultures of Swiss 3T3 and C3H/10T1/2CL8 mouse cells treated with 5-azacytidine or 5-aza-2'-deoxycytidine, implying that cell division was obligatory for the expression of the new phenotypes.
Journal ArticleDOI
Phenotypic conversion of cultured mouse embryo cells by aza pyrimidine nucleosides
TL;DR: The induction of myotubes by 5-azacytidine in cells synchronized by two different methods required that treatment with the analog was carried out at a critical phase early in S phase, suggesting the mechanism of drug action appears to be linked to specific DNA synthesis.