S
Shiv I. S. Grewal
Researcher at National Institutes of Health
Publications - 99
Citations - 20281
Shiv I. S. Grewal is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Heterochromatin & Heterochromatin assembly. The author has an hindex of 61, co-authored 95 publications receiving 19125 citations. Previous affiliations of Shiv I. S. Grewal include Cold Spring Harbor Laboratory & Laboratory of Molecular Biology.
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Journal ArticleDOI
Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi.
Tom Volpe,Catherine A. Kidner,Ira M. Hall,Ira M. Hall,Grace Teng,Grace Teng,Shiv I. S. Grewal,Robert A. Martienssen +7 more
TL;DR: It is proposed that double-stranded RNA arising from centromeric repeats targets formation and maintenance of heterochromatin through RNAi.
Journal ArticleDOI
Role of Histone H3 Lysine 9 Methylation in Epigenetic Control of Heterochromatin Assembly
TL;DR: In vivo evidence is provided that lysine 9 of histone H3 (H3 Lys9) is preferentially methylated by the Clr4 protein at heterochromatin-associated regions in fission yeast, defining a conserved pathway wherein sequential histone modifications establish a “histone code” essential for the epigenetic inheritance of heterochROMatin assembly.
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RNAi-Mediated Targeting of Heterochromatin by the RITS Complex
André Verdel,Songtao Jia,Scott A. Gerber,Tomoyasu Sugiyama,Steven P. Gygi,Shiv I. S. Grewal,Danesh Moazed +6 more
TL;DR: The purification of an RNAi effector complex termed RITS (RNA-induced initiation of transcriptional gene silencing) that is required for heterochromatin assembly in fission yeast is described and a mechanism for the role of the RNAi machinery and small RNAs in targeting of heterochROMatin complexes and epigenetic genesilencing at specific chromosomal loci is suggested.
Journal ArticleDOI
Heterochromatin and Epigenetic Control of Gene Expression
Shiv I. S. Grewal,Danesh Moazed +1 more
TL;DR: An unexpected role for noncoding RNAs and RNA interference in the formation of epigenetic chromatin domains has been uncovered.
Journal ArticleDOI
Establishment and Maintenance of a Heterochromatin Domain
Ira M. Hall,Gurumurthy D. Shankaranarayana,Ken-ichi Noma,Nabieh Ayoub,Amikam Cohen,Shiv I. S. Grewal,Shiv I. S. Grewal +6 more
TL;DR: It is demonstrated that a centromere-homologous repeat present at the silent mating-type region is sufficient for heterochromatin formation at an ectopic site, and that its repressive capacity is mediated by components of the RNA interference (RNAi) machinery.