S
Shivalingappa Venkatesha
Researcher at Beth Israel Deaconess Medical Center
Publications - 9
Citations - 2743
Shivalingappa Venkatesha is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Vascular endothelial growth factor A & Preeclampsia. The author has an hindex of 9, co-authored 9 publications receiving 2537 citations. Previous affiliations of Shivalingappa Venkatesha include Harvard University & Yale University.
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Journal ArticleDOI
Soluble endoglin contributes to the pathogenesis of preeclampsia.
Shivalingappa Venkatesha,Mourad Toporsian,Chun Lam,Jun-ichi Hanai,Tadanori Mammoto,Yeon Mee Kim,Yeon Mee Kim,Yuval Bdolah,Kee-Hak Lim,Hai Tao Yuan,Towia A. Libermann,Isaac E. Stillman,Drucilla J. Roberts,Patricia A. D'Amore,Franklin H. Epstein,Frank W. Sellke,Roberto Romero,Roberto Romero,Vikas P. Sukhatme,Michelle Letarte,S. Ananth Karumanchi +20 more
TL;DR: A novel placenta-derived soluble TGF-β coreceptor, endoglin (sEng), which is elevated in the sera of preeclamptic individuals, correlates with disease severity and falls after delivery, suggest that sEng may act in concert with sFlt1 to induce severe preeclampsia.
Journal ArticleDOI
Sequential Changes in Antiangiogenic Factors in Early Pregnancy and Risk of Developing Preeclampsia
Sarosh Rana,S. Ananth Karumanchi,Richard J. Levine,Shivalingappa Venkatesha,Jose Alejandro Rauh-Hain,Hector Tamez,Ravi Thadhani +6 more
TL;DR: Sequential changes in antiangiogenic factors during early pregnancy may be useful for predicting preterm preeclampsia.
Journal ArticleDOI
Soluble Fms-like tyrosine kinase 1 and endothelial dysfunction in the pathogenesis of preeclampsia.
TL;DR: Recent evidence is described that supports a novel mechanism in which a maladaptive shift in placental production of angiogenic factors such as soluble fms-like tyrosine kinase 1 (a circulating antiangiogenic protein) may play an important role in the pathogenesis of preeclampsia.
Journal ArticleDOI
VEGF and TGF-β are required for the maintenance of the choroid plexus and ependyma
Arindel S.R. Maharaj,Tony E. Walshe,Magali Saint-Geniez,Shivalingappa Venkatesha,Shivalingappa Venkatesha,Angel E. Maldonado,Nathan Himes,Kabir S. Matharu,S. Ananth Karumanchi,S. Ananth Karumanchi,Patricia A. D'Amore +10 more
TL;DR: Results provide compelling evidence that both VEGF and TGF-β are involved in the regulation of EC stability, ependymal cell function, and periventricular permeability.
Journal ArticleDOI
Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival
Hai Tao Yuan,Shivalingappa Venkatesha,Barden Chan,Urban Deutsch,Tadanori Mammoto,Vikas P. Sukhatme,Adrian S. Woolf,S. Ananth Karumanchi +7 more
TL;DR: It is shown that a main role for Tiel is to modulate blood vessel morphogenesis by virtue of its ability to down‐regulate Tie2‐driven signaling and endothelial survival.