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Showing papers by "Shizuo Akira published in 1994"

Journal Article•DOI•
Cytokine signal transduction

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Tadamitsu Kishimoto1, Tetsuya Taga1, Shizuo Akira1•
Osaka University1
28 Jan 1994-Cell
TL;DR: Clinical Cancer Research is published monthly, one volume per year, by the American Association for Cancer Research, Inc.

1,290 citations

Journal Article•DOI•
Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway

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Shizuo Akira1, Yukihiro Nishio1, Masahiro Inoue1, Xue-Jie Wang1, Shi We1, Taiji Matsusaka1, Kanji Yoshida1, Tetsuo Sudo2, Masanobu Naruto2, Tadamitsu Kishimoto1 •
Osaka University1, Toray Industries2
08 Apr 1994-Cell
TL;DR: The purification and cloning of APRF are reported and it is observed that p91 is not tyrosine phosphorylated in response to IL-6, and that selective activation of p91-related factors may explain the diversity of cellular responses to different cytokines.

997 citations

Journal Article•DOI•
Preliminary evidence that overexpression of nuclear factor for IL6 expression (NF-IL6) in NIH3T3 cells may be related to malignant transformation

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Minsheng Zhu1, Dinggan Liu1, Shizuo Akira2, Zaiping Li1•
Academia Sinica1, Osaka University2
01 Dec 1994-Cell Research
TL;DR: The results suggest that NF-IL6 may be related to tumorigenesis, and the stable integration of NF- IL6 cDNA into cellular DNA and its expression were demonstrated.
Abstract: NF-IL6 is a member of c/EBP family and has multiple functions in regulation of cellular gene expression. We have constructed NF-IL6 expression plasmids and transfected the NIH3T3 cells with them. The sense NF-IL6 transfectants showed significantly increased tumorigenicity, and the stable integration of NF-IL6 cDNA into cellular DNA and its expression were demonstrated. Our results suggest that NF-IL6 may be related to tumorigenesis.

1 citations