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Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
Stat-3 is required for pulmonary homeostasis during hyperoxia
Isamu Hokuto,Machiko Ikegami,Mitsuhiro Yoshida,Kiyoshi Takeda,Shizuo Akira,Anne-Karina T. Perl,William M. Hull,Susan E. Wert,Jeffrey A. Whitsett +8 more
TL;DR: Exposure of adult Stat-3-deleted mice to 95% oxygen caused a more rapidly progressive lung injury associated with alveolar capillary leak and acute respiratory distress, and intratracheal treatment with exogenous surfactant protein B improved survival and lung histology in Stat- 3-deletes mice during hyperoxia.
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Loss of mRor1 Enhances the Heart and Skeletal Abnormalities in mRor2-Deficient Mice: Redundant and Pleiotropic Functions of mRor1 and mRor2 Receptor Tyrosine Kinases
Masashi Nomi,Isao Oishi,Shuichi Kani,Hiroaki Suzuki,Takeru Matsuda,Akinori Yoda,Makiko Kitamura,Kyoko Itoh,Shigeto Takeuchi,Kiyoshi Takeda,Shizuo Akira,Makoto Ikeya,Shinji Takada,Yasuhiro Minami +13 more
TL;DR: It is shown thatmRor1-deficient mice have no apparent skeletal or cardiac abnormalities, yet they also die soon after birth due to respiratory dysfunction, indicating that mROr1 and mRor2 interact genetically in skeletal and cardiac development.
Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins 1
Osamu Takeuchi,Shintaro Sato,Takao Horiuchi,Katsuaki Hoshino,Kiyoshi Takeda,Zhongyun Dong,Robert L. Modlin,Shizuo Akira +7 more
TL;DR: Taken together, TLR1 interacts with TLR2 to recognize the lipid configuration of the native mycobacterial lipoprotein as well as several triacylated lipopeptides.
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Lymphocytoid Choriomeningitis Virus Activates Plasmacytoid Dendritic Cells and Induces a Cytotoxic T-Cell Response via MyD88
Andreas Jung,Hiroki Kato,Yutaro Kumagai,Himanshu Kumar,Taro Kawai,Osamu Takeuchi,Shizuo Akira +6 more
TL;DR: Results suggest that recognition of LCMV by plasmacytoid DCs via TLRs is responsible for the production of type I IFNs in vivo, and the activation of a MyD88-dependent innate mechanism induces a CTL response, which eventually leads to virus elimination.
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Dual Role of TLR2 and Myeloid Differentiation Factor 88 in a Mouse Model of Invasive Group B Streptococcal Disease
Giuseppe Mancuso,Angelina Midiri,Concetta Beninati,Carmelo Biondo,Roberta Galbo,Shizuo Akira,Philipp Henneke,Philipp Henneke,Douglas T. Golenbock,Giuseppe Teti +9 more
TL;DR: A dual role of TLR2 and MyD88 in the host defense against GBS sepsis is highlighted and TNF-α is strongly suggested as the molecular mediator of bacterial clearance and septic shock.