S
Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
Role of Mouse and Human Autophagy Proteins in IFN-γ–Induced Cell-Autonomous Responses against Toxoplasma gondii
Jun Ohshima,Youngae Lee,Miwa Sasai,Tatsuya Saitoh,Ji Su Ma,Naganori Kamiyama,Yoshiharu Matsuura,Suh Pann-Ghill,Mikako Hayashi,Shigeyuki Ebisu,Kiyoshi Takeda,Shizuo Akira,Masahiro Yamamoto +12 more
TL;DR: It is shown that essential autophagy proteins differentially participate in anti–T.
Journal ArticleDOI
Early type I interferon-mediated signals on B cells specifically enhance antiviral humoral responses.
Katja Fink,Karl S. Lang,Nataly Manjarrez-Orduño,Nataly Manjarrez-Orduño,Tobias Junt,Beatrice M. Senn,Beatrice M. Senn,Martin Holdener,Martin Holdener,Shizuo Akira,Rolf M. Zinkernagel,Hans Hengartner +11 more
TL;DR: It is shown that IFN‐α‐mediated augmentation of specific B cell responses is a partially TLR7‐ and virus dose‐dependent mechanism and directly fuel early humoral immune responses in vivo.
Journal ArticleDOI
Differential Role of MyD88 in Macrophage-Mediated Responses to Opportunistic Fungal Pathogens
Kieren A. Marr,Kieren A. Marr,S. Arunmozhi Balajee,Thomas R. Hawn,Thomas R. Hawn,Adrian Ozinsky,Uyenvy Pham,Shizuo Akira,Alan Aderem,W. Conrad Liles +9 more
TL;DR: Results provide evidence that MyD88 signaling is involved in phagocytosis and killing of live C. albicans yeasts and hyphae, and may represent one mechanism by which macrophages regulate innate responses specific to different pathogenic fungi.
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Herpes simplex virus infection is sensed by both Toll-like receptors and retinoic acid-inducible gene- like receptors, which synergize to induce type I interferon production.
Simon B. Rasmussen,Søren B. Jensen,Christoffer Nielsen,Emanuel Quartin,Hiroki Kato,Zhijian J. Chen,Robert H. Silverman,Shizuo Akira,Søren R. Paludan +8 more
TL;DR: In this article, the authors showed that retinoic acid-inducible gene (RIG)-I-like receptors (RLRs) in cooperation with Toll-like receptor (TLR) 9 are required for expression of type I interferons (IFNs) after infection with herpes simplex virus (HSV).
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Membrane-Bound Prostaglandin E Synthase-1-Mediated Prostaglandin E2 Production by Osteoblast Plays a Critical Role in Lipopolysaccharide-Induced Bone Loss Associated with Inflammation
TL;DR: LPS binds to TLR4 on osteoblasts that directly induce mPGES-1 expression for PGE2 synthesis, leading to subsequent bone resorption, and may provide a new target for the treatment of inflammatory bone disease.