S
Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure
Takafumi Oka,Shungo Hikoso,Osamu Yamaguchi,Manabu Taneike,Manabu Taneike,Toshihiro Takeda,Takahito Tamai,Jota Oyabu,Tomokazu Murakawa,Hiroyuki Nakayama,Kazuhiko Nishida,Kazuhiko Nishida,Shizuo Akira,Akitsugu Yamamoto,Issei Komuro,Kinya Otsu,Kinya Otsu +16 more
TL;DR: It is shown that mitochondrial DNA that escapes from autophagy cell-autonomously leads to Toll-like receptor (TLR) 9-mediated inflammatory responses in cardiomyocytes and is capable of inducing myocarditis and dilated cardiopathy in DNase II-deficient mice.
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Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.
Taiji Matsusaka,Keiko Fujikawa,Yukihiro Nishio,Naofumi Mukaida,Koji Matsushima,Tadamitsu Kishimoto,Shizuo Akira +6 more
TL;DR: The synergistic activation of the IL-6 promoter by transcription factors NF-IL6 and NF-kappa B and the possible interplay between various viral gene products and these two factors in the process of viral infection and constitutive cytokine production is discussed.
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Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
Franck J. Barrat,Thea Meeker,Josh Gregorio,Jean H. Chan,Satoshi Uematsu,Shizuo Akira,Bonnie Chang,Omar Duramad,Robert L. Coffman +8 more
TL;DR: It is shown that mammalian DNA and RNA, in the form of ICs, are potent self-antigens for TLR9 and TLR7, respectively, and induce IFN-α production by PDCs, suggesting that TLRs may have a critical role in the promotion of lupus through the induction of IFn-α by P DCs.
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Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.
Fuminori Tokunaga,Shin-ichi Sakata,Shin-ichi Sakata,Yasushi Saeki,Yoshinori Satomi,Takayoshi Kirisako,Kiyoko Kamei,Kiyoko Kamei,Tomoko Nakagawa,Tomoko Nakagawa,Michiko Kato,Shigeo Murata,Shigeo Murata,Shoji Yamaoka,Masahiro Yamamoto,Shizuo Akira,Toshifumi Takao,Keiji Tanaka,Kazuhiro Iwai,Kazuhiro Iwai +19 more
TL;DR: Results indicate that LUBAC is involved in the physiological regulation of the canonical NF-κB activation pathway through linear polyubiquitylation of NEMO.
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Stimulation of the vagus nerve attenuates macrophage activation by activating the Jak2-STAT3 signaling pathway.
Wouter J. de Jonge,Esmerij P. van der Zanden,Maarten F. Bijlsma,David J van Westerloo,Roelof J. Bennink,Hans-Rudolf Berthoud,Satoshi Uematsu,Shizuo Akira,Rene M. van den Wijngaard,Guy E. Boeckxstaens +9 more
TL;DR: In a mouse model of intestinal manipulation, stimulation of the vagus nerve ameliorated surgery-induced inflammation and postoperative ileus by activating STAT3 in intestinal macrophages and it is concluded that the vagal anti-inflammatory pathway acts by α7 subunit–mediated Jak2-STAT3 activation.