S
Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
Papers
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Journal ArticleDOI
Lipocalin 2 bolsters innate and adaptive immune responses to blood-stage malaria infection by reinforcing host iron metabolism.
Hong Zhao,Aki Konishi,Yukiko Fujita,Masanori Yagi,Keiichi Ohata,Taiki Aoshi,Sawako Itagaki,Shintaro Sato,Hirotaka Narita,Noha H. Abdelgelil,Megumi Inoue,Richard Culleton,Osamu Kaneko,Atsushi Nakagawa,Toshihiro Horii,Shizuo Akira,Ken Ishii,Cevayir Coban +17 more
TL;DR: It is determined that Lipocalin 2 (Lcn2), a host protein that sequesters iron, is abundantly secreted during human and mouse blood-stage malaria infections and is essential to control P. yoeliiNL parasitemia, anemia, and host survival.
Book ChapterDOI
TIR domain-containing adaptors regulate TLR signaling pathways.
Masahiro Yamamoto,Shizuo Akira +1 more
TL;DR: Accumulating evidence clearly demonstrates that Toll-like receptors serve as pattern recognition receptors to detect invading microbes.
Journal ArticleDOI
Increased atherosclerotic lesions and Th17 in interleukin-18 deficient apolipoprotein E-knockout mice fed high-fat diet.
Nada Pejnovic,Athanassios Vratimos,Sang Hee Lee,Dusan Popadic,Kiyoshi Takeda,Shizuo Akira,Woon Ling Chan +6 more
TL;DR: It is suggested that in IL-18 deficiency, cholesterol in HCD synergize mechanistically with homocysteine to accelerate atherosclerosis via the alternative IL-23/Th17 pathway, demonstrating a new role for Th17 in Atherosclerosis.
Journal ArticleDOI
Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial products
Jenna B. Allard,Lisa Rinaldi,Matthew J. Wargo,Gilman B. Allen,Shizuo Akira,Satoshi Uematsu,Matthew E. Poynter,Deborah A. Hogan,Mercedes Rincon,Laurie A. Whittaker +9 more
TL;DR: It is shown that oropharyngeal aspiration of fungal lysates promotes airway eosinophilia, secretion of Th2 cytokines and mucus cell metaplasia, and the immunomodulatory effect that bacterial lysate have on the response to fungi is TLR4 independent but MyD88 dependent.
Journal ArticleDOI
Downregulation of STAT3 activation is required for presumptive rod photoreceptor cells to differentiate in the postnatal retina.
Yoko Ozawa,Keiko Nakao,Takuya Shimazaki,Junji Takeda,Shizuo Akira,Katsuhiko Ishihara,Toshio Hirano,Yoshihisa Oguchi,Hideyuki Okano +8 more
TL;DR: In this paper, it was shown that STAT3 activation, but not SHP2 activation, is responsible for the CNTF/gp130 signaling that inhibits expression of Rhodopsin and its upstream activator, crx, in the retinal explants derived from P0 mice.