S
Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
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Journal ArticleDOI
Tak1 is a Component of the Epstein-Barr Virus Lmp1 Complex and is Essential for Activation of JNK But Not of NF-κB
Noriyuki Uemura,Taisuke Kajino,Hideki Sanjo,Shintaro Sato,Shizuo Akira,Kunihiro Matsumoto,Jun Ninomiya-Tsuji +6 more
TL;DR: Results suggest that an LMP1-associated complex containing TRAF6, TAB2, and TAK1 plays an essential role in the activation of JNK, however, TAK 1 is not an exclusive intermediate for NF-κB activation in L MP1 signaling.
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Innate immunity in allergy
TL;DR: New insights into the innate immune system by sensors and their signaling cascades provide more important clues and a framework for understanding allergy disorders.
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Cytokine-induced injury of the lacrimal and salivary glands.
Akiko Kimura-Shimmyo,Shin-ichiro Kashiwamura,Haruyasu Ueda,Tomohiro Ikeda,Sanae Kanno,Shizuo Akira,Kenji Nakanishi,Osamu Mimura,Haruki Okamura +8 more
TL;DR: It is suggested that these cytokines can mediate apoptosis in glandular epithelial cells and that the elevated NO production is responsible for the change.
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Potent Antimycobacterial Activity of Mouse Secretory Leukocyte Protease Inhibitor
Junichi Nishimura,Hiroyuki Saiga,Shintaro Sato,Megumi Okuyama,Hisako Kayama,Hirotaka Kuwata,Sohkichi Matsumoto,Toshirou Nishida,Yoshiki Sawa,Shizuo Akira,Yasunobu Yoshikai,Masahiro Yamamoto,Kiyoshi Takeda +12 more
TL;DR: Recombinant mouse SLPI effectively inhibited in vitro growth of bacillus Calmette-Guérin and Mycobacterium tuberculosis through disruption of the mycobacterial cell wall structure.
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IL-1R-associated kinase 4 is required for lipopolysaccharide-induced activation of APC.
Nobutaka Suzuki,Shinobu Suzuki,Urs Eriksson,Hiromitsu Hara,Christine Mirtosis,Nien Jung Chen,Teiji Wada,Denis Bouchard,Irene Hwang,Kiyoshi Takeda,Takashi Fujita,Sandy D. Der,Josef M. Penninger,Shizuo Akira,Takashi Saito,Wen Chen Yeh +15 more
TL;DR: It is demonstrated that IRAK-4 is critical for the LPS-induced activations of APCs and for the proper maturation of dendritic cells by LPS stimulation, particularly in terms of cytokine production and the ability to stimulate Th cell differentiation.