S
Shizuo Akira
Researcher at Osaka University
Publications - 1330
Citations - 344469
Shizuo Akira is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 261, co-authored 1308 publications receiving 320561 citations. Previous affiliations of Shizuo Akira include University of California, Berkeley & Wakayama Medical University.
Papers
More filters
Journal ArticleDOI
Regnase-1, a Ribonuclease Involved in the Regulation of Immune Responses
TL;DR: Regnase-1 protein is cleaved by Malt1 and inactivated in response to T-cell receptor stimulation, and is a key molecule in the regulation of immune responses.
Journal ArticleDOI
Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages.
Hisashi Kanemaru,Fumihiro Yamane,Kiyoharu Fukushima,Takanori Matsuki,Takahiro Kawasaki,Isao Ebina,Kanako Kuniyoshi,Hiroki Tanaka,Kenta Maruyama,Kazuhiko Maeda,Takashi Satoh,Shizuo Akira +11 more
TL;DR: It is found that basic leucine zipper transcription factor ATF-like 2 (Batf2) has an antitumor effect through the up-regulation of IL-12 p40 in tumor-associated macrophages, which eventually induces CD8+ T-cell activation and accumulation within the tumor.
Book ChapterDOI
A nuclear factor for the IL-6 gene (NF-IL6).
Shizuo Akira,Hiroshi Isshiki,Toshihiro Nakajima,Shigemi Kinoshita,Yukihiro Nishio,Shigeru Hashimoto,Shunji Natsuka,Tadamitsu Kishimoto +7 more
Journal ArticleDOI
Nucleic acid sensing by T cells initiates Th2 cell differentiation
Takayuki Imanishi,Chitose Ishihara,Mohamed E.l.Sherif G.adelhaq Badr,Akiko Hashimoto-Tane,Yayoi Kimura,Taro Kawai,Osamu Takeuchi,Ken Ishii,Shun'ichiro Taniguchi,Tetsuo Noda,Hisashi Hirano,Frank Brombacher,Glen N. Barber,Shizuo Akira,Takashi Saito +14 more
TL;DR: It is shown that unlike in innate cells, T-cell costimulation is induced even by non-CpG DNA and by self-DNA, which is released from dead cells and complexes with antimicrobial peptides or histones.
Journal ArticleDOI
Limited role of the Toll-like receptor-2 in resistance to Mycobacterium avium
M. Salomé Gomes,Manuela Flórido,João V. Cordeiro,C. Miguel Teixeira,Osamu Takeuchi,Shizuo Akira,Rui Appelberg +6 more
TL;DR: Data show that TLR‐2 is required for optimal immunity against certain virulent M. avium strains that were able to proliferate in vivo before the development of protective immunity and mycobacteriostasis.