Shizuo Akira

TL;DR: It is demonstrated that TLR5 expression by dendritic cells (DCs) allows a 1,000-fold enhancement of T-cell sensitivity to flagellin, and this enhancement did not require the expression of NLRC4 or Myd88.

TL;DR: It is demonstrated that an overexpression of IDO within the airway epithelium represents a novel mechanism by which the number of CD4(+) T cells recruited to the lung and their capacity to produce cytokines can be diminished in a model of allergic airway disease, and these results also highlight the critical role of dendritic cells in the antiasthmatic effects of IDo induction by CpG DNA.

TL;DR: The data demonstrate that a single cytokine, LIF, can simultaneously and independently affect both RPE and photoreceptors through the same signaling cascade to reduce the generation and utilization of 11-cis-retinal.

TL;DR: From the analyses of c/.v-regulatory elements in the acute-phase protein genes and the nuclear factors binding to these elements, two transcription factors, NF-IL6 and APRF/STAT3.

TL;DR: It is concluded that NF-IL-6 is a critical transcription factor in mycobacterial control as well as in granulocyte-colony stimulating factor induction resulting in neutrophil activation.